Trial reportBMC veterinary research2017
Sero-prevalence of virus neutralizing antibodies for rabies in different groups of dogs following vaccination.
Trial report in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Enhanced immunogenicity of the rabies virus glycoprotein fused to a dendritic cell-targeting peptide.Scientific reports · 2026Article
- Immunogenicity of anti-rabies vaccines (ARVs) marketed in Sri Lanka: a comparative study.Clinical and experimental vaccine research · 2026Article
- Bayesian modeling of post-vaccination serological data suggests that yearly vaccination of dog aged <2 years old is efficient to stop rabies circulation in Cambodia.PLoS neglected tropical diseases · 2024Article
- Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment.The American journal of tropical medicine and hygiene · 2023Article
- Assessment of Immune Responses to Rabies Vaccination in Free-Ranging Dogs in Bengaluru, India.Vaccines · 2023Article
- Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia.BMC veterinary research · 2023Article
- Factors Associated with Dog Rabies Immunization in Changsha, China: Results of a Cross-Sectional Cluster Survey, 2015-2021.Viruses · 2022Article
- Understanding the incidence and timing of rabies cases in domestic animals and wildlife in south-east Tanzania in the presence of widespread domestic dog vaccination campaigns.Veterinary research · 2022Article
- Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.EFSA journal. European Food Safety Authority · 2022Article
- Investigation of protective level of rabies antibodies in vaccinated dogs in Chennai, India.Veterinary record open · 2021Article
- Loss of binding antibodies against rabies in a vaccinated dog population in Flores Island, Indonesia.PLoS neglected tropical diseases · 2021Article
- Immunization Coverage and Antibody Retention against Rabies in Domestic Dogs in Lusaka District, Zambia.Pathogens (Basel, Switzerland) · 2021Article
- Immunogenicity of the Oral Rabies Vaccine Strain SPBN GASGAS in Dogs Under Field Settings in Namibia.Frontiers in veterinary science · 2021Article
- Modelling the challenges of managing free-ranging dog populations.Scientific reports · 2020Article
- Article
- Risk assessment on rabies entry through hunting dog movement with semi-quantitative approach to Sumatera Island, Indonesia.Journal of advanced veterinary and animal research · 2019Article
- Serological profiling of rabies antibodies by enzyme-linked immunosorbent assay and its comparative analysis with rapid fluorescent focus inhibition test in mouse model.Veterinary world · 2019Article
- Strategies to maintain Korea's animal rabies non-occurrence status.Clinical and experimental vaccine research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMass vaccination of dogs is considered fundamental for national rabies control programmes in Sri Lanka, as dog is the main reservoir and transmitter of the disease.
methodsDogs were followed to determine the sero-prevalence of antibodies to the rabies virus. Altogether 510 previously vaccinated and unvaccinated dogs with owners (domestic dogs) and dogs without owners (stray dogs) of the local guard dog breed in different age groups recruited from Kalutara District, Sri Lanka. The dogs were vaccinated with a monovalent inactivated vaccine intramuscularly and serum antibody titres on days 0, 30, 180 and 360 were determined by the Rapid Fluorescent Focus Inhibition Test (RFFIT).
resultsThe results indicated, a single dose of anti-rabies vaccination fails to generate a protective level of immunity (0.5 IU/ml) which lasts until 1 year in 40.42% of dogs without owners and 57.14% of previously unvaccinated juvenile (age: 3 months to 1 year) dogs with owners. More than one vaccination would help to maintain antibody titres above the protective level in the majority of dogs. The pattern of antibody titre development in annually vaccinated and irregularly vaccinated (not annual) adult dogs with owners is closely similar irrespective of regularity in vaccination. Previously vaccinated animals have higher (2 IU/ml) antibody titres to begin with and have a higher antibody titre on day 360 too. They show a very good antibody titre by day 180. Unvaccinated animals start with low antibody titre and return to low titres by day 360, but have a satisfactory antibody titre by day 180.
conclusionsA single dose of anti-rabies vaccination is not sufficient for the maintenance of antibody titres for a period of 1 year in puppies, juvenile dogs with owners and in dogs without owners. Maternal antibodies do not provide adequate protection to puppies of previously vaccinated dams and puppies of previously unvaccinated dams. Immunity development after vaccination seems to be closely similar in both the groups of puppies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.