ArticleRespiratory research2017
Genome-wide association study of subclinical interstitial lung disease in MESA.
Article in Respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Limited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients.BMC nephrology · 2022Pooled it
- Mapping the human genetic architecture of COVID-19.Nature · 2021Pooled it
- Deviations from genetic additivity driven by rare variants at biobank scale.Nature communications · 2026Article
- Association between gut microbiota and chronic diseases in East Asian ethnicity: A two-sample Mendelian randomization study.Medicine · 2026Observational
- Current diagnosis, epidemiology, and management of interstitial lung abnormalities.Frontiers in medicine · 2026Review
- SARS-CoV-2-encoded miR-nsp3-3p promotes pulmonary fibrosis by inhibiting expression of ALCAM.Virologica Sinica · 2025Article
- [Research Progress of Anti-lung Cancer Drug-related Interstitial Lung Disease].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Review
- TEMR: Trans-ethnic mendelian randomization method using large-scale GWAS summary datasets.American journal of human genetics · 2025Article
- Prediction and assessment of deleterious and disease causing nonsynonymous single nucleotide polymorphisms (nsSNPs) in humanHeliyon · 2024Article
- Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.BMC infectious diseases · 2024Article
- The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis.European journal of cell biology · 2023Article
- Genetic Associations with Coronavirus Susceptibility and Disease Severity.Advances in experimental medicine and biology · 2023Review
- The human genetic epidemiology of COVID-19.Nature reviews. Genetics · 2022Review
- The genetic and evolutionary determinants of COVID-19 susceptibility.European journal of human genetics : EJHG · 2022Review
- Associations of sleep duration and sleep-wake rhythm with lung parenchymal abnormalities on computed tomography: The MESA study.Journal of sleep research · 2022Article
- Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents.Frontiers in medicine · 2022Review
- SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues.Cell reports · 2021Article
- Host genetic factors determining COVID-19 susceptibility and severity.EBioMedicine · 2021Review
- Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity.medRxiv : the preprint server for health sciences · 2021Article
- Interstitial lung abnormalities - current knowledge and future directions.European clinical respiratory journal · 2021Review
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundWe conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis Study.
methodsWe measured the percentage of high attenuation areas (HAA) in the lung fields on cardiac CT scan defined as voxels with CT attenuation values between -600 and -250 HU. Genetic analyses were performed in MESA combined across race/ethnic groups: non-Hispanic White (n = 2,434), African American (n = 2,470), Hispanic (n = 2,065) and Chinese (n = 702), as well as stratified by race/ethnicity.
resultsAmong 7,671 participants, regions at genome-wide significance were identified for basilar peel-core ratio of HAA in FLJ35282 downstream of ANRIL (rs7852363, P = 2.1x10
conclusionsOur results suggest novel roles for protein glycosylation and cell cycle disinhibition by long non-coding RNA in the pathogenesis of ILD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.