Evidence map›Paper›PMID 28521694›Full record

ReviewCurrent pharmaceutical design2017

Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering.

Arti Vashist, Ajeet Kaushik, Kayla Alexis, Rahul Dev Jayant, Vidya Sagar, Atul Vashist, Madhavan Nair

Abstract readReview
In one paragraph

Review in Current pharmaceutical design, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Therapeutic peptides and proteins: Status and developments in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  11. Article
  12. Spatiotemporal control of CRISPR/Cas9 gene editing.Signal transduction and targeted therapy · 2021
    Review
  13. pH-Sensitive Biomaterials for Drug Delivery.Molecules (Basel, Switzerland) · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arti VashistCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.
Ajeet KaushikCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.
Kayla AlexisCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.
Rahul Dev JayantCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.
Vidya SagarCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.
Atul VashistDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029. India.
Madhavan NairCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.

Funding

Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug AbusersR01DA042706 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI KHALILI, KAMEL, NAIR, MADHAVAN P. · 2016 to 2020
$3.2M
Polydrug Nanocarrier to Treat Opiate Addiction and HIV DiseaseR01DA027049 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2009 to 2014
$3.1M
To evaluate the role of cannabinoid signaling during the comorbidity of HIV and Alzheimer¿s disease in the context of HIV-associated cognitive disordersR01DA040537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2015 to 2019
$3.0M
Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2R01DA034547 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2013 to 2018
$1.8M
Multifunctional Nanocarrier to Eradicate HIV from latently infected CNS cells andR01DA037838 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2014 to 2018
$1.8M
NIDA NIH HHS R01 DA027049NIDA NIH HHS R01 DA034547NIDA NIH HHS R01 DA037838NIDA NIH HHS R01 DA040537NIDA NIH HHS R01 DA042706
6 · The paper itself

Abstract

The emergence of injectable hydrogels as biomaterials has been a revolutionary breakthrough in the field of on-demand drug delivery and tissue engineering. The promising features of these systems include their biodegradability, biocompatibility, permeability, ease of the surgical implantation, and most importantly exhibit minimally invasiveness. These hydrogels have been explored as sustained and on-demand release carriers for the various bioactive agents, growth factors, live cells, various hydrophobic drugs and as extracellular matrices for tissue engineering. Present review is an attempt to highlight the recent systems explored for on-demand drug release and tissue engineering. It also gives an overview of the role of nanotechnology in the advancements of injectable hydrogels. The future prospects and challenges of these hydrogels have also been addressed.

Indexed as

AnimalsBiocompatible MaterialsDrug Delivery SystemsDrug LiberationHumansHydrogelsInjectionsNanocompositesTissue EngineeringBiocompatible MaterialsHydrogelsbiomaterialschitosandrug deliveryInjectable hydrogelsnanomedicinenanotechnologypluronics

Identifiers

PMID28521694
PMCPMC6889087

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.