ArticleJournal of endourology2017
Detection and Evaluation of Renal Injury in Burst Wave Lithotripsy Using Ultrasound and Magnetic Resonance Imaging.
Article in Journal of endourology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Burst Wave Lithotripsy (BWL) for the Comminution of Urinary Tract Stones: Intraoperative Evaluation of Safety and Effectiveness
Ultrasound Technology to Fragment and Reposition Urinary Stones
Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- First In-Human Burst Wave Lithotripsy for Kidney Stone Comminution: Initial Two Case Studies.Journal of endourology · 2021Trial
- Burst wave lithotripsy - a paradigm shift: inferences from a scoping review.World journal of urology · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Biomechanical Modelling of Porcine Kidney.Bioengineering (Basel, Switzerland) · 2024Article
- Development of a burst wave lithotripsy system for noninvasive fragmentation of ureteroliths in pet cats.BMC veterinary research · 2023Article
- Functional and Morphological Changes Associated with Burst Wave Lithotripsy-Treated Pig Kidneys.Journal of endourology · 2022Article
- First Series Using Ultrasonic Propulsion and Burst Wave Lithotripsy to Treat Ureteral Stones.The Journal of urology · 2022Article
- Fragmentation of Stones by Burst Wave Lithotripsy in the First 19 Humans.The Journal of urology · 2022Article
- Recent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion.BME frontiers · 2022Article
- Factors Affecting Tissue Cavitation during Burst Wave Lithotripsy.Ultrasound in medicine & biology · 2021Article
- Article
- Design, fabrication, and characterization of broad beam transducers for fragmenting large renal calculi with burst wave lithotripsy.The Journal of the Acoustical Society of America · 2020Article
- An investigation of elastic waves producing stone fracture in burst wave lithotripsy.The Journal of the Acoustical Society of America · 2020Article
- Burst wave lithotripsy and acoustic manipulation of stones.Current opinion in urology · 2020Review
- Evaluation of Renal Stone Comminution and Injury by Burst Wave Lithotripsy in a Pig Model.Journal of endourology · 2019Article
- Article
- Innovations in Ultrasound Technology in the Management of Kidney Stones.The Urologic clinics of North America · 2019Review
- Impact of stone characteristics on cavitation in burst wave lithotripsy.Proceedings of meetings on acoustics. Acoustical Society of America · 2018Article
- An in vivo demonstration of efficacy and acute safety of burst wave lithotripsy using a porcine model.Proceedings of meetings on acoustics. Acoustical Society of America · 2018Article
- Update on clinical trials of kidney stone repositioning and preclinical results of stone breaking with one system.Proceedings of meetings on acoustics. Acoustical Society of America · 2018Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
purposeBurst wave lithotripsy (BWL) is a transcutaneous technique with potential to safely and effectively fragment renal stones. Preclinical investigations of BWL require the assessment of potential renal injury. This study evaluates the capabilities of real-time ultrasound and MRI to detect and evaluate BWL injury that was induced in porcine kidneys. MATERIALS AND
methodsTen kidneys from five female farm pigs were treated with either a 170 or 335 kHz BWL transducer using variable treatment parameters and monitored in real-time with ultrasound. Eight kidneys were perfusion fixed and scanned with a 3-Tesla MRI scanner (T1-weighted, T2-weighted, and susceptibility-weighted imaging), followed by processing via an established histomorphometric technique for injury quantification. In addition, two kidneys were separately evaluated for histologic characterization of injury quality.
resultsObserved B-mode hyperechoes on ultrasound consistent with cavitation predicted the presence of BWL-induced renal injury with a sensitivity and specificity of 100% in comparison to the histomorphometric technique. Similarly, MRI detected renal injury with a sensitivity of 90% and specificity of 100% and was able to identify the scale of lesion volumes. The injuries purposefully generated with BWL were histologically similar to those formed by shock wave lithotripsy.
conclusionsBWL-induced renal injury can be detected with a high degree of sensitivity and specificity by real-time ultrasound and post-treatment ex vivo MRI. No injury occurred in this study without cavitation detected on ultrasound. Such capabilities for injury detection and lesion volume quantification on MRI can be used for preclinical testing of BWL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.