ArticleOncology letters2017
Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence.
Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Podoplanin immunoexpression in odontogenic lesions: a systematic review, meta-analysis, and integrated bioinformatic analysis.Diagnostic pathology · 2024Pooled it
- Recurrence of Glandular Odontogenic Cysts: A Systematic Review.Head and neck pathology · 2024Pooled it
- Conservative surgical treatments for nonsyndromic odontogenic keratocysts: a systematic review and meta-analysis.Clinical oral investigations · 2018Pooled it
- A clinical study on the preservation of pulp sensitivity in affected teeth with jaw cysts using concentrated growth factor: a retrospective Cross-sectional study.Scientific reports · 2025Article
- Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws.Journal of maxillofacial and oral surgery · 2024Article
- Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Lymphangiogenesis in Odontogenic Keratocysts Compared with Dentigerous Cysts.Journal of dentistry (Shiraz, Iran) · 2024Article
- A 3-year follow-up clinical study on the preservation for vitality of involved tooth in jaw cysts through an innovative method.Scientific reports · 2024Article
- Appearance and recurrence of odontogenic keratocysts.Clinical and experimental dental research · 2023Article
- Odontogenic Keratocysts: Presentation and Surgical Outcome in a Sample of Sudanese Patients.International journal of dentistry · 2023Article
- Evaluating histopathological factors of predicting the recurrence rate of odontogenic keratocyst.Dental research journal · 2023Article
- Histological changes in odontogenic parakeratinized keratocysts treated with marsupialization followed by enucleation.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Computerized Evaluation of the Immunoexpression of Ki-67 Protein in Odontogenic Keratocyst and Dentigerous Cyst.Head and neck pathology · 2020Article
- Recurrence of odontogenic keratocysts and possible prognostic factors: Review of 455 patients.Medicina oral, patologia oral y cirugia bucal · 2019Article
- Investigation of clinicopathological parameters and expression of COX-2, bcl-2, PCNA, and p53 in primary and recurrent sporadic odontogenic keratocysts.Clinical oral investigations · 2018Article
- Cysts and Pseudocysts of the Oral Cavity: Revision of the Literature and a New Proposed Classification.In vivo (Athens, Greece)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated. The presence of daughter cysts, epithelial islands and high Ki-67, CD34 and podoplanin expression levels were revealed to be associated with tumor recurrence. In particular, univariate analysis revealed that high CD34 expression levels were significantly associated with tumor recurrence (P=0.034), as was conservative surgical treatment (P=0.003). Multivariate analysis revealed that conservative treatment was the greatest independent risk factor for tumor recurrence (odds ratio=13.337; P=0.018). These results suggest that overexpression of CD34 may be a potent predictor of tumor recurrence and radical treatment of the teeth that are in contact with the tumors is recommended in order to prevent tumor recurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.