ArticleNeuron2017
Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 98 citations in OpenAlex.
- Distinct Contributions and Sensorimotor Encoding of PV and FoxP2 Neurons in the External Globus Pallidus during Perceptual Decision-making.Neuroscience bulletin · 2026Article
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Brain-inspired strategies for efficient artificial intelligence.Molecules and cells · 2026Review
- Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior.bioRxiv : the preprint server for biology · 2026Article
- Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior.Cell reports · 2026Article
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- A Distinct Circuit for Biasing Visual Perceptual Decisions and Modulating Superior Colliculus Activity through the Mouse Posterior Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Principal axis of primate basal ganglia in processing cognitive flexibility and habitual stability.Brain : a journal of neurology · 2025Review
- A distinct circuit for biasing visual perceptual decisions and modulating superior colliculus activity through the mouse posterior striatum.bioRxiv : the preprint server for biology · 2025Article
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- Reward monitoring in the frontopolar cortex of macaques.Scientific reports · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.Research square · 2025Article
- Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.bioRxiv : the preprint server for biology · 2024Article
- Convergent representation of values from tactile and visual inputs for efficient goal-directed behavior in the primate putamen.Nature communications · 2024Article
- Pupil dilation reflects effortful action invigoration in overcoming aversive Pavlovian biases.Cognitive, affective & behavioral neuroscience · 2024Article
- Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.Neuroscience and biobehavioral reviews · 2024Review
- Article
- Value-Based Search Efficiency Is Encoded in the Substantia Nigra Reticulata Firing Rate, Spiking Irregularity and Local Field Potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System.Current neuropharmacology · 2024Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The striatum controls behavior in two ways: facilitation and suppression through the direct and indirect pathways, respectively. However, it is still unclear what information is processed in these pathways. To address this question, we studied two pathways originating from the primate caudate tail (CDt). We found that the CDt innervated the caudal-dorsal-lateral part of the substantia nigra pars reticulata (cdlSNr), directly or indirectly through the caudal-ventral part of the globus pallidus externus (cvGPe). Notably, cvGPe neurons receiving inputs from the CDt were mostly visual neurons that encoded stable reward values of visual objects based on long-past experiences. Their dominant response was inhibition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibition of superior colliculus neurons. Our data suggest that low-value signals are sent by the CDt-indirect pathway to suppress saccades to valueless objects, whereas high-value signals are sent by the CDt-direct pathway to facilitate saccades to valuable objects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.