Evidence map›Paper›PMID 28521005›Full record

ArticleSchizophrenia bulletin2017

Using Directed Acyclic Graphs in Epidemiological Research in Psychosis: An Analysis of the Role of Bullying in Psychosis.

Giusi Moffa, Gennaro Catone, Jack Kuipers, Elizabeth Kuipers, Daniel Freeman, Steven Marwaha, Belinda R Lennox, Matthew R Broome, Paul Bebbington

Open access · bronzeAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 151 citations in OpenAlex.

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  14. Identifying potential action points for reducing kinesiophobia among atrial fibrillation patients: a network and DAG analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Giusi MoffaDivision of Psychiatry, University College London, London, UK.
Gennaro CatoneDepartment of Mental and Physical Health and Preventive Medicine, University of Naples SUN, Naples, Italy.
Jack KuipersD-BSSE, ETH Zurich, Basel, Switzerland.
Elizabeth KuipersDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Daniel FreemanDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Steven MarwahaDivision of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK.
Belinda R LennoxDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Matthew R BroomeDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Paul BebbingtonDivision of Psychiatry, University College London, London, UK.
Warneford Hospital · GBETH Zurich · CHSouth London and Maudsley NHS Foundation Trust · GBUniversità degli Studi Suor Orsola Benincasa · ITUniversity College London · GBUniversity Hospital of Basel · CHUniversity of Oxford · GBUniversity of Warwick · GB

Funding

Department of Health RP-2014-05-003
6 · The paper itself

Abstract

Modern psychiatric epidemiology researches complex interactions between multiple variables in large datasets. This creates difficulties for causal inference. We argue for the use of probabilistic models represented by directed acyclic graphs (DAGs). These capture the dependence structure of multiple variables and, used appropriately, allow more robust conclusions about the direction of causation. We analyzed British national survey data to assess putative mediators of the association between bullying victimization and persecutory ideation. We compared results using DAGs and the Karlson-Holm-Breen (KHB) logistic regression commands in STATA. We analyzed data from the 2007 English National Survey of Psychiatric Morbidity, using the equivalent 2000 survey in an instant replication. Additional details of methods and results are provided in the supplementary material. DAG analysis revealed a richer structure of relationships than could be inferred using the KHB logistic regression commands. Thus, bullying had direct effects on worry, persecutory ideation, mood instability, and drug use. Depression, sleep and anxiety lay downstream, and therefore did not mediate the link between bullying and persecutory ideation. Mediation by worry and mood instability could not be definitively ascertained. Bullying led to hallucinations indirectly, via persecutory ideation and depression. DAG analysis of the 2000 dataset suggested the technique generates stable results. While causality cannot be fully determined from cross-sectional data, DAGs indicate the relationships providing the best fit. They thereby advance investigation of the complex interactions seen in psychiatry, including the mechanisms underpinning psychiatric symptoms. It may consequently be used to optimize the choice of intervention targets.

Indexed as

AnxietyBullyingCrime VictimsDelusionsDepressionModels, StatisticalPsychotic DisordersAdultHealth SurveysHumansUnited Kingdomanxietybullyingdepressiondirected acyclic graphsmediationpersecutory ideationprobabilistic graphical modelspsychosisworry

Identifiers

PMID28521005
PMCPMC5737513
OpenAlexW2616641613

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.