ArticleAmerican journal of epidemiology2017
Dietary Intake of Antioxidant Vitamins and Carotenoids and Risk of Developing Active Tuberculosis in a Prospective Population-Based Cohort Study.
Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- The Impact of Vitamin A Deficiency on Tuberculosis Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Hypercoagulability in Pulmonary Tuberculosis: Reduced Protein C and Free Protein S Predict Pulmonary Embolism-Evidence from a Prospective Romanian Cohort.Journal of clinical medicine · 2026Article
- Intake of dietary carotenoids and flavonoids at midlife and risk of physical frailty at late life: the Singapore Chinese Health Study.Nutrition journal · 2025Article
- Unveiling the properties of ascorbic acid against M. tb through in silico approach: A comparative drug-based study.Journal of molecular modeling · 2025Article
- Hypercoagulability in Tuberculosis: Pathophysiological Mechanisms, Associated Risks, and Advances in Management-A Narrative Review.Journal of clinical medicine · 2025Review
- Vitamin C and Tuberculosis: Examining the Relationship Between Antioxidant Defense and Disease Severity-Preliminary Findings from a Southwestern Romanian Study.Journal of clinical medicine · 2024Article
- Spatial spillover effect of environmental factors on the tuberculosis occurrence among the elderly: a surveillance analysis for nearly a dozen years in eastern China.BMC public health · 2024Article
- A pro-oxidant property of vitamin C to overcome the burden of latentFrontiers in cellular and infection microbiology · 2023Review
- Tuberculosis in an Aging World.Pathogens (Basel, Switzerland) · 2022Review
- Joint Associations of Multiple Lifestyle Factors With Risk of Active Tuberculosis in the Population: The Singapore Chinese Health Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Avoiding pitfalls in calculating the population attributable fraction of undernutrition for TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Article
- Potential Role of Vitamins A, B, C, D and E in TB Treatment and Prevention: A Narrative Review.Antibiotics (Basel, Switzerland) · 2021Review
- Association of Dietary Micronutrient Intake with Pulmonary Tuberculosis Treatment Failure Rate: ACohort Study.Nutrients · 2020Article
- N-Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis.Tuberculosis research and treatment · 2020Review
- Asthma, Sinonasal Disease, and the Risk of Active Tuberculosis.The journal of allergy and clinical immunology. In practice · 2019Article
- THE AUTHORS REPLY.American journal of epidemiology · 2018Article
- Alcohol drinking and cigarette smoking in relation to risk of active tuberculosis: prospective cohort study.BMJ open respiratory research · 2017Article
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5 authors.
Funding
Abstract
Antioxidants may protect against oxidative stress, which is associated with tuberculosis (TB) disease. However, direct evidence for a protective association between dietary antioxidants and TB incidence in humans has been lacking. The relationship between intake of antioxidant vitamins (vitamins A, C, D, and E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein) and TB incidence was examined in the Singapore Chinese Health Study, a prospective cohort study of 63,257 adults aged 45-74 years enrolled during 1993-1998. Baseline intake of these antioxidants was estimated using a validated semiquantitative food frequency questionnaire including questions on use of dietary supplements. After an average of 16.9 years of follow-up, 1,186 incident active TB cases were identified among cohort participants. Compared with the lowest quartile, reduced risk of active TB was observed for the highest quartile of vitamin A intake (hazard ratio = 0.71, 95% confidence interval: 0.59, 0.85; P-trend < 0.01) and β-carotene intake (hazard ratio = 0.76, 95% confidence interval: 0.63, 0.91; P-trend < 0.01), regardless of smoking status. Lower TB risk was seen for vitamin C intake among current smokers only. Other vitamins and carotenoids were not associated with TB risk. These results suggest that vitamin C may reduce TB risk among current smokers by ameliorating oxidative stress, while vitamin A and β-carotene may have additional antimycobacterial properties.
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