ArticleSchizophrenia bulletin2018
Altered White Matter Connectivity Within and Between Networks in Antipsychotic-Naive First-Episode Schizophrenia.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurostructural, Neurofunctional, and Clinical Features of Chronic, Untreated Schizophrenia: A Narrative Review.Schizophrenia bulletin · 2025Pooled it
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning.Schizophrenia (Heidelberg, Germany) · 2026Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- The modular mind and psychiatry: toward clinical integration with a focus on self-disorders.Frontiers in psychology · 2025Article
- Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia.Molecular neurobiology · 2024Article
- Negative symptoms are associated with modularity and thalamic connectivity in schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum.Schizophrenia bulletin · 2022Article
- Subcortical Brain Morphometry Differences between Adults with Autism Spectrum Disorder and Schizophrenia.Brain sciences · 2022Article
- White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Artificial intelligence applications in psychoradiology.Psychoradiology · 2021Article
- Multimodal assessment of white matter microstructure in antipsychotic-naïve schizophrenia patients and confounding effects of recreational drug use.Brain imaging and behavior · 2021Article
- Disruption of Conscious Access in Psychosis Is Associated with Altered Structural Brain Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Assessment of Vascular Network Connectivity of Hepatocellular Carcinoma Using Graph-Based Approach.Frontiers in oncology · 2021Article
- Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss.Frontiers in neuroscience · 2021Article
- White matter microstructure and network-connectivity in emerging adults with subclinical psychotic experiences.Brain imaging and behavior · 2020Article
- [A preliminary study on schizophrenia of distinct antipsychotic response based on diffusion tensor imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- White Matter Microstructure across the Psychosis Spectrum.Trends in neurosciences · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analyzing the schizophrenia connectome can identify illness-related alterations in connectivity across the brain. An important question that remains unanswered is whether connectivity alterations are already evident at the onset of illness, before treatment with antipsychotic medication and possible influences of neuroprogressive or secondary alterations related to chronic illness duration. In the present study, diffusion tensor imaging and deterministic fiber tractography were performed with 137 antipsychotic-naive first-episode schizophrenia patients and 113 matched healthy controls. Using graph theoretic analysis, groups were compared in global and regional measurements and modularity of white matter connectivity. Compared with controls, the patients showed significantly decreased total connection strength. Furthermore, patients demonstrated significantly decreased connections within and between brain modules. Several local brain regions within association cortex exhibited reduced nodal centralities and abnormal participant coefficient or intra-module degree, some of which were correlated with illness duration and overall functional disability. In never-treated schizophrenia patients, networks showed a less effective organizational pattern of white matter pathways. White matter disconnectivity occurred not only within but also between multiple modules, shedding light on the deficits of anatomical network organization early in the course of schizophrenia.
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