ArticleThe Journal of infectious diseases2017
Increased Urinary Trimethylamine N-Oxide Following Cryptosporidium Infection and Protein Malnutrition Independent of Microbiome Effects.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions.Engineering in life sciences · 2024Review
- Fecal microbiota impacts development of Cryptosporidium parvum in the mouse.Scientific reports · 2024Article
- ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers.Pharmaceutics · 2023Review
- Microbiome-Metabolomics Analysis of the Impacts ofMicrobiology spectrum · 2023Article
- Gut Fungal Microbiome Responses to NaturalFrontiers in microbiology · 2022Article
- Pheromones that correlate with reproductive success in competitive conditions.Scientific reports · 2021Article
- Modeling Enteropathy or Diarrhea with the Top Bacterial and Protozoal Pathogens: Differential Determinants of Outcomes.ACS infectious diseases · 2021Review
- Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention.Nutrients · 2019Review
- Metabolic phenotyping of malnutrition during the first 1000 days of life.European journal of nutrition · 2019Review
- Article
- Disentangling Microbial Mediators of Malnutrition: Modeling Environmental Enteric Dysfunction.Cellular and molecular gastroenterology and hepatology · 2019Review
- Amixicile Reduces Severity of Cryptosporidiosis but Does Not HaveAntimicrobial agents and chemotherapy · 2018Article
- Critical Role of Zinc in a New Murine Model of Enterotoxigenic Escherichia coli Diarrhea.Infection and immunity · 2018Article
- A novel mouse model of Campylobacter jejuni enteropathy and diarrhea.PLoS pathogens · 2018Article
Corrections and comments
- Erratum issuedErrata.2018
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Cryptosporidium infections have been associated with growth stunting, even in the absence of diarrhea. Having previously detailed the effects of protein deficiency on both microbiome and metabolome in this model, we now describe the specific gut microbial and biochemical effects of Cryptosporidium infection. Protein-deficient mice were infected with Cryptosporidium parvum oocysts for 6-13 days and compared with uninfected controls. Following infection, there was an increase in the urinary excretion of choline- and amino-acid-derived metabolites. Conversely, infection reduced the excretion of the microbial-host cometabolite (3-hydroxyphenyl)propionate-sulfate and disrupted metabolites involved in the tricarboxylic acid (TCA) cycle. Correlation analysis of microbial and biochemical profiles resulted in associations between various microbiota members and TCA cycle metabolites, as well as some microbial-specific degradation products. However, no correlation was observed between the majority of the infection-associated metabolites and the fecal bacteria, suggesting that these biochemical perturbations are independent of concurrent changes in the relative abundance of members of the microbiota. We conclude that cryptosporidial infection in protein-deficient mice can mimic some metabolic changes seen in malnourished children and may help elucidate our understanding of long-term metabolic consequences of early childhood enteric infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.