Evidence map›Paper›PMID 28520869›Full record

ArticlePathogens and disease2017

Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers.

Yun-Juan Bao, Yang Li, Zhong Liang, Garima Agrahari, Shaun W Lee, Victoria A Ploplis, Francis J Castellino

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Canada-Wide Epidemic ofOpen forum infectious diseases · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun-Juan BaoW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Yang LiW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Zhong LiangW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Garima AgrahariW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Shaun W LeeW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Victoria A PloplisW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Francis J CastellinoW.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.

Funding

STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Plasminogen and Plasmin: Structure and FunctionR56HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 2022 to 2022
$743k
STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR37HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J · 1990 to 1999
–
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R37 HL013423NHLBI NIH HHS R56 HL013423
6 · The paper itself

Abstract

The strains serotyped as M71 from group A Streptococcus are common causes of pharyngeal and skin diseases worldwide. Here we characterize the genome of a unique non-invasive M71 human isolate, NS53. The genome does not contain structural rearrangements or large-scale gene gains/losses, but encodes a full set of non-truncated known virulence factors, thus providing an ideal reference for comparative studies. However, the NS53 genome showed incongruent phenotypic implications from distinct genotypic markers. NS53 is characterized as an emm pattern D and FCT (fibronectin-collagen-T antigen) type-3 strain, typical of skin tropic strains, but is phylogenetically close to emm pattern E strains with preference for both skin and pharyngeal infections. We propose that this incongruence could result from recombination within the emm gene locus, or, alternatively, selection has been against those genetic alterations. Combined with the inability to select for CovS switching, a process is indicated whereby NS53 has been pre-adapted to specific host niches selecting against variations in CovS and many other genes. This may allow the strain to attain successful colonization and long-term survival. A balance between genetic variations and fitness may exist for this bacterium to form a stabilized genome optimized for survival in specific host environments.

Indexed as

Genome, BacterialGenotypePhenotypeAdaptation, BiologicalGenetic VariationHumansPhylogenySerogroupStreptococcal InfectionsStreptococcus pyogenesVirulenceVirulence FactorsVirulence Factorsgenetic markersinvasivephylogenetic structureStreptococcus pyogenesvirulence factors

Identifiers

PMID28520869
PMCPMC5808649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.