SynthesisPloS one2017
Comparative accuracy of CT perfusion in diagnosing acute ischemic stroke: A systematic review of 27 trials.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Cost-effectiveness of CT perfusion, low-field MRI, and delayed high-field MRI in emergency department patients with dizziness concerning for stroke.Neuroradiology · 2026Article
- Emergency MRI in acute dizziness and headache: current insights and future directions.Frontiers in neurology · 2026Review
- How Do Patient Outcomes in Mechanical Thrombectomy for Large-Core Stroke Vary Based on Neuroimaging Modalities Used for Patient Selection? A Multicenter Multinational Study.Translational stroke research · 2025Article
- Assessing the accuracy of automated CT perfusion software in excluding acute stroke: a comparative study of two software packages.Frontiers in neuroimaging · 2025Article
- Predictive Utility of PLR and Platelet-to-LDL Ratio for in-Stent Restenosis Following Carotid Artery Stenting.Vascular health and risk management · 2025Article
- Spectral imaging and analysis of monophasic CT angiography to assess infarct core and penumbra in acute stroke.Scientific reports · 2024Article
- Enhancing Stroke Recognition: A Comparative Analysis of Balance and Eyes-Face, Arms, Speech, Time (BE-FAST) and Face, Arms, Speech, Time (FAST) in Identifying Posterior Circulation Strokes.Journal of clinical medicine · 2024Article
- Abbreviated MRI in the evaluation of dizziness: report turnaround times and impact on length of stay compared to CT, CTA, and conventional MRI.Emergency radiology · 2024Article
- Regional Reliability of Combining CT Angiography-source Image and Non-contrast CT in Acute Ischemic Stroke.International journal of medical sciences · 2024Article
- Characteristics of peripheral immune response induced by large-vessel occlusion in patients with acute ischemic stroke.Frontiers in neurology · 2024Article
- Contemporary Methods for Detection and Intervention of Distal Medium and Small Vessel Occlusions.Journal of clinical medicine · 2023Review
- Assessing the Relationship between LAMS and CT Perfusion Parameters in Acute Ischemic Stroke Secondary to Large Vessel Occlusion.Journal of clinical medicine · 2023Article
- Pictorial Review on Imaging Findings in Cerebral CTP in Patients with Acute Stroke and Its Mimics: A Primer for General Radiologists.Diagnostics (Basel, Switzerland) · 2023Review
- Incorporating algorithmic uncertainty into a clinical machine deep learning algorithm for urgent head CTs.PloS one · 2023Article
- Clinical utility of MRI in acute stroke beyond reperfusion therapy.Journal of family medicine and primary care · 2022Article
- Stroke Mimics in the Acute Setting: Role of Multimodal CT Protocol.AJNR. American journal of neuroradiology · 2022Article
- Artificial intelligence for localization of the acute ischemic stroke by non-contrast computed tomography.PloS one · 2022Article
- Predictive Value of CT Brain Perfusion Studies in Acute Ischemic Infarct Taking MRI Stroke Protocol As Gold Standard.Cureus · 2021Article
- Dual-energy computed tomography in acute ischemic stroke: state-of-the-art.European radiology · 2021Review
- Cost-Effectiveness Study of Initial Imaging Selection in Acute Ischemic Stroke Care.Journal of the American College of Radiology : JACR · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically evaluate and compare the diagnostic accuracy of CT perfusion (CTP), non-enhanced computed tomography (NCCT) and computed tomography angiography (CTA) in detecting acute ischemic stroke.
methodsWe searched seven databases and screened the reference lists of the included studies. The risk of bias in the study quality was assessed using QUADASII. We produced paired forest plots in RevMan to show the variation of the sensitivity and specificity estimates together with their 95% CI. We used a hierarchical summary ROC model to summarize the sensitivity and specificity of CTP in detecting ischemic stroke.
resultsWe identified 27 studies with a total of 2168 patients. The pooled sensitivity of CTP for acute ischemic stroke was 82% (95% CI 75-88%), and the specificity was 96% (95% CI 89-99%). CTP was more sensitive than NCCT and had a similar accuracy with CTA. There were no statistically significant differences in the sensitivity and specificity between patients who underwent CTP within 6 hours of symptom onset and beyond 6 hours after symptom onset. No adverse events were reported in the included studies.
conclusionsCTP is more accurate than NCCT and has similar accuracy to CTA in detecting acute ischemic stroke. However, the evidence is not strong. There is potential benefit of using CTP to select stroke patients for treatment, but more high-quality evidence is needed to confirm this result.
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