Evidence map›Paper›PMID 28520584›Full record

ReviewCurrent opinion in pediatrics2017

Eating disorders and bone metabolism in women.

Lauren Robinson, Nadia Micali, Madhusmita Misra

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Bone Fracture History in Women With First Episode or With Persistent Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Article
  4. The current clinical approach to feeding and eating disorders aimed to increase personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
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  11. Article
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  18. Exome sequencing in a familial form of anorexia nervosa supports multigenic etiology.Journal of neural transmission (Vienna, Austria : 1996) · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Lauren RobinsonaInstitute of Child Health, University College London, UK bDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, New York cPediatric Endocrine and Neuroendocrine Units, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nadia Micali
Madhusmita Misra
Icahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · USUniversity College London · GB

Funding

RESEARCH TRAINING IN MENTAL RETARDATIONT32HD007184 · NICHD · UNIVERSITY OF NOTRE DAME · PI BORKOWSKI, JOHN G · 1985 to 2010
$1.4M
Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NICHD NIH HHS K24 HD071843NICHD NIH HHS T32 HD007184
6 · The paper itself

Abstract

purpose of reviewEating Disorders are psychiatric disorders associated with a high risk for low bone mineral density (BMD) and fractures. Low BMD is a consequence of undernutrition, changes in body composition, and hormonal alterations. This review summarizes recent findings regarding novel strategies for assessing bone outcomes in patients with eating disorders, factors contributing to altered bone metabolism, and possible therapeutic strategies. RECENT

findingsEmerging research in this field suggests that not only anorexia nervosa, but also bulimia nervosa results in lower BMD compared to controls. To date studies of bone structure, and all randomized controlled trials examining the impact of various therapies on bone outcomes in anorexia nervosa, have focused on adolescent girls and women. We discuss the impact of anorexia nervosa on bone structure, and associations of resting energy expenditure, marrow adipose tissue (including the ratio of saturated to unsaturated fat), and cold activated brown adipose tissue with BMD and bone structure. Promising strategies for treatment include physiological estrogen replacement (rather than oral contraceptives) in adolescent girls with anorexia nervosa, and bisphosphonates, as well as teriparatide, in adult women with anorexia nervosa. SUMMARY: Recent data on (i) BMD and bone structure in adolescent girls and women with eating disorders, (ii) factors that contribute to altered bone metabolism, and (iii) randomized controlled trials reporting positive effects of physiologic estrogen replacement, bisphosphonates and teriparatide on bone health, provide us with a greater understanding of the impact of eating disorders on bone and novel management strategies.

Indexed as

Absorptiometry, PhotonBiomarkersBody CompositionBone DensityBone Density Conservation AgentsBone RemodelingEnergy MetabolismFeeding and Eating DisordersFemaleHumansOsteoporosisBiomarkersBone Density Conservation Agents

Identifiers

PMID28520584
PMCPMC5675561
OpenAlexW2614782044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.