ArticleMolecular plant pathology2018
Verticillium dahliae transcription factor VdFTF1 regulates the expression of multiple secreted virulence factors and is required for full virulence in cotton.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Article
- The acyl-CoA-binding protein VdAcb1 is essential for carbon starvation response and contributes to virulence inaBIOTECH · 2024Article
- Dual Transcriptome Analysis Reveals the Changes in Gene Expression in Both Cotton andJournal of fungi (Basel, Switzerland) · 2024Article
- The Transcription Factor SsZNC1 Mediates Virulence, Sclerotial Development, and Osmotic Stress Response inJournal of fungi (Basel, Switzerland) · 2024Article
- Genomic insights intoFrontiers in microbiology · 2024Review
- Deleting an xylosidase-encoding geneFrontiers in microbiology · 2024Article
- Article
- CeGAL: Redefining a Widespread Fungal-Specific Transcription Factor Family Using an In Silico Error-Tracking Approach.Journal of fungi (Basel, Switzerland) · 2023Article
- Identification of sugar transporter genes and their roles in the pathogenicity ofFrontiers in plant science · 2023Article
- Interactions betweenFrontiers in plant science · 2023Review
- Transcription Factor VdCf2 Regulates Growth, Pathogenicity, and the Expression of a Putative Secondary Metabolism Gene Cluster in Verticillium dahliae.Applied and environmental microbiology · 2022Article
- The secretome of Verticillium dahliae in collusion with plant defence responses modulates Verticillium wilt symptoms.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Identification of VdASP F2-interacting protein as a regulator of microsclerotial formation in Verticillium dahliae.Microbial biotechnology · 2022Article
- A polyketide synthase from Verticillium dahliae modulates melanin biosynthesis and hyphal growth to promote virulence.BMC biology · 2022Article
- The Transcription FactorFrontiers in microbiology · 2022Article
- Computational Analysis of HTS Data and Its Application in Plant Pathology.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The NecrotrophFrontiers in plant science · 2022Article
- The heat shock factor GhHSFA4a positively regulates cotton resistance toFrontiers in plant science · 2022Article
- Integrative transcriptomic and gene co-expression network analysis of host responses upon Verticillium dahliae infection in Gossypium hirsutum.Scientific reports · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal transcription factors (TFs) implicated in the regulation of virulence gene expression have been identified in a number of plant pathogens. In Verticillium dahliae, despite its agricultural importance, few regulators of transcription have been characterized. In this study, a T-DNA insertion mutant with significantly reduced virulence towards cotton was identified. The T-DNA was traced to VdFTF1, a gene encoding a TF containing a Fungal_trans domain. Transient expression in onion epidermal cells indicated that VdFTF1 is localized to the nucleus. The VdFTF1-deletion strains displayed normal vegetative growth, mycelial pigmentation and conidial morphology, but exhibited significantly reduced virulence on cotton, suggesting that VdFTF1 is required exclusively for pathogenesis. Comparisons of global transcription patterns of wild-type and VdFTF1-deletion strains indicated that VdFTF1 affected the expression of 802 genes, 233 of which were associated with catalytic processes. These genes encoded 69 potentially secreted proteins, 43 of which contained a carbohydrate enzyme domain known to participate in pathogenesis during infection of cotton. Targeted gene deletion of one VdFTF1-regulated gene resulted in significantly impaired vascular colonization, as measured by quantitative polymerase chain reaction, as well as aggressiveness and symptom severity in cotton. In conclusion, VdFTF1, which encodes a TF containing a Fungal_trans domain, regulates the gene expression of plant cell wall degradation enzymes in V. dahliae, which are required for full virulence on cotton.
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