ArticleCell death & disease2017
RACK1 depletion in the ribosome induces selective translation for non-canonical autophagy.
Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A B1 SINE element within the mouseScience advances · 2026Article
- Translation in proximity to forming autophagosomes during sustained autophagy.Nature communications · 2026Article
- Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- RACK1 in host immune response to infections: molecular mechanisms and therapeutic potentials.Frontiers in immunology · 2026Review
- Insights into the regulation of mRNA translation by scaffolding proteins.Biochemical Society transactions · 2024Review
- Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity.Journal of cellular and molecular medicine · 2024Article
- Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration.Cell communication and signaling : CCS · 2024Review
- Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration.Neuron · 2023Article
- RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication.Journal of virology · 2022Article
- Specialised ribosomes as versatile regulators of gene expression.RNA biology · 2022Review
- Preventing translational inhibition from ribosomal protein insufficiency by a herpes simplex virus-encoded ribosome-associated protein.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome.Cell reports · 2021Article
- RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly.Cell reports · 2020Article
- Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15.Cell death and differentiation · 2020Article
- Autophagy Regulation by the Translation Machinery and Its Implications in Cancer.Frontiers in oncology · 2020Review
- Article
- Does functional specialization of ribosomes really exist?RNA (New York, N.Y.) · 2019Review
- Disruption of the Putative Ribosome-Binding Motif of a Scaffold Protein Impairs CytochromemSphere · 2019Article
- Translational Reprogramming Provides a Blueprint for Cellular Adaptation.Cell chemical biology · 2018Article
- eIF5A is required for autophagy by mediating ATG3 translation.EMBO reports · 2018Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RACK1, which was first demonstrated as a substrate of PKCβ II, functions as a scaffold protein and associates with the 40S small ribosomal subunit. According to previous reports, ribosomal RACK1 was also suggested to control translation depending on the status in translating ribosome. We here show that RACK1 knockdown induces autophagy independent of upstream canonical factors such as Beclin1, Atg7 and Atg5/12 conjugates. We further report that RACK1 knockdown induces the association of mRNAs of LC3 and Bcl-xL with polysomes, indicating increased translation of these proteins. Therefore, we propose that the RACK1 depletion-induced autophagy is distinct from canonical autophagy. Finally, we confirm that cells expressing mutant RACK1 (RACK1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.