ArticleJournal of visualized experiments : JoVE2017
A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity.
Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Choosing a skull clearing technique for chronic mesoscopic optical imaging in awake mice.Neurophotonics · 2026Article
- The Optically Guided and Pre-assembled Implantation Cranial Window Reveals Cortical Spatial Representations during Navigation.Research (Washington, D.C.) · 2026Article
- SeeThrough: a rationally designed skull clearing technique for in vivo brain imaging.Nature communications · 2025Article
- Sensory experience selectively reorganizes the late component of evoked responses.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Anesthesia and analgesia for common research models of adult mice.Laboratory animal research · 2022Review
- Combining Cortical Voltage Imaging and Hippocampal Electrophysiology for Investigating Global, Multi-Timescale Activity Interactions in the Brain.International journal of molecular sciences · 2022Article
- Electroacupuncture attenuates surgical pain-induced delirium-like behavior in miceFrontiers in immunology · 2022Article
- The "WWHow" Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats.Frontiers in veterinary science · 2022Article
- Prenatal stress dysregulates resting-state functional connectivity and sensory motifs.Neurobiology of stress · 2021Article
- Article
- In silico exploration of mouse brain dynamics by focal stimulation reflects the organization of functional networks and sensory processing.Network neuroscience (Cambridge, Mass.) · 2020Article
- High-performance, inexpensive setup for simultaneous multisite recording of electrophysiological signals and mesoscale voltage imaging in the mouse cortex.Neurophotonics · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The craniotomy is a commonly performed procedure to expose the brain for in vivo experiments. In mouse research, most labs utilize a small craniotomy, typically 3 mm x 3 mm. This protocol introduces a method for creating a substantially larger 7 mm x 6 mm cranial window exposing most of a cerebral hemisphere over the mouse temporal and parietal cortices (e.g., bregma 2.5 - 4.5 mm, lateral 0 - 6 mm). To perform this surgery, the head must be tilted approximately 30° and much of the temporal muscle must be retracted. Due to the large amount of bone removal, this procedure is intended only for acute experiments with the animal anesthetized throughout the surgery and experiment. The main advantage of this innovative large lateral cranial window is to provide simultaneous access to both medial and lateral areas of the cortex. This large unilateral cranial window can be used to study the neural dynamics between cells, as well as between different cortical areas by combining multi-electrode electrophysiological recordings, imaging of neuronal activity (e.g., intrinsic or extrinsic imaging), and optogenetic stimulation. Additionally, this large craniotomy also exposes a large area of cortical blood vessels, allowing for direct manipulation of the lateral cortical vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.