ArticleMolecular and cellular biology1988
The Drosophila melanogaster tropomyosin II gene produces multiple proteins by use of alternative tissue-specific promoters and alternative splicing.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- The transcriptional landscape of the giant freshwater prawn: Embryonic development and early sexual differentiation mechanisms.Frontiers in endocrinology · 2022Article
- Nanoscopy reveals the layered organization of the sarcomeric H-zone and I-band complexes.The Journal of cell biology · 2020Article
- Comparative Analysis of Brain and Fat Body Gene Splicing Patterns in the Honey Bee,G3 (Bethesda, Md.) · 2019Article
- A Beetle Flight Muscle Displays Leg Muscle Microstructure.Biophysical journal · 2016Article
- PEP1 of Arabis alpina is encoded by two overlapping genes that contribute to natural genetic variation in perennial flowering.PLoS genetics · 2012Article
- Regulating the contraction of insect flight muscle.Journal of muscle research and cell motility · 2011Review
- Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.Gene expression patterns : GEP · 2007Article
- The structural role of high molecular weight tropomyosins in dipteran indirect flight muscle and the effect of phosphorylation.Journal of muscle research and cell motility · 2006Article
- The Sequence Ontology: a tool for the unification of genome annotations.Genome biology · 2005Article
- Two functionally identical modular enhancers in Drosophila troponin T gene establish the correct protein levels in different muscle types.Molecular biology of the cell · 2004Article
- Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A tropomyosin-2 mutation suppresses a troponin I myopathy in Drosophila.Molecular biology of the cell · 2001Article
- Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis.Genetics · 1998Article
- Alterations in flight muscle ultrastructure and function in Drosophila tropomyosin mutants.The Journal of cell biology · 1996Article
- Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation.The EMBO journal · 1996Article
- Interspecific sequence comparison of the muscle-myosin heavy-chain genes from Drosophila hydei and Drosophila melanogaster.Journal of molecular evolution · 1994Article
- Article
- A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant.Journal of muscle research and cell motility · 1993Article
- Polymorphism in a Drosophila indirect flight muscle-specific tropomyosin isozyme does not affect flight ability.Biochemical genetics · 1992Article
- Avian cardiac tropomyosin gene produces tissue-specific isoforms through alternative RNA splicing.Journal of muscle research and cell motility · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The structure of the Drosophila melanogaster tropomyosin II (TmII) gene has been determined by DNA sequencing of cDNA clones and the genomic DNA coding for the gene. Two overlapping transcriptional units produce at least four different tropomyosin isoforms. A combination of developmentally regulated promoters and alternative splicing produces both muscle and cytoskeletal tropomyosin isoforms. One promoter is a muscle-specific promoter and produces three different tropomyosin isoforms by alternative splicing of the last three 3' exons. The second promoter has the characteristics of a housekeeping promoter and produces a cytoskeletal tropomyosin isoform. Several internal exons along with a final 3' exon are alternatively spliced in the cytoskeletal transcript. The intron-exon boundaries of the TmII gene are identical to the intron-exon boundaries of all vertebrate tropomyosin genes reported, but are very different from the intron-exon boundaries of the D. melanogaster tropomyosin I gene. The TmII gene is the only reported tropomyosin gene that has two promoters and a quadruple alternative splice choice for the final exon. Models for the mechanism of D. melanogaster tropomyosin gene evolution are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.