ArticleMolecular and cellular biology1988
Transpositional competence and transcription of endogenous Ty elements in Saccharomyces cerevisiae: implications for regulation of transposition.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Determinants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3.Viruses · 2016Review
- The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.PLoS genetics · 2015Article
- Article
- P-body components are required for Ty1 retrotransposition during assembly of retrotransposition-competent virus-like particles.Molecular and cellular biology · 2010Article
- S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1.Molecular and cellular biology · 2007Article
- Article
- Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance.Genetics · 2001Article
- An active retrotransposon in Candida albicans.Nucleic acids research · 2001Article
- Posttranslational regulation of Ty1 retrotransposition by mitogen-activated protein kinase Fus3.Molecular and cellular biology · 1998Article
- Yeast retrotransposon Ty4: the majority of the rare transcripts lack a U3-R sequence.Nucleic acids research · 1996Article
- Heterogeneous functional Ty1 elements are abundant in the Saccharomyces cerevisiae genome.Genetics · 1994Article
- Ectopic recombination between Ty elements in Saccharomyces cerevisiae is not induced by DNA damage.Molecular and cellular biology · 1992Article
- Posttranslational control of Ty1 retrotransposition occurs at the level of protein processing.Molecular and cellular biology · 1992Article
- The population biology and evolutionary significance of Ty elements in Saccharomyces cerevisiae.Genetica · 1992Review
- Proteolytic processing of pol-TYB proteins from the yeast retrotransposon Ty1.Journal of virology · 1991Article
- Multimeric arrays of the yeast retrotransposon Ty.Molecular and cellular biology · 1990Article
- Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition.Molecular and cellular biology · 1990Article
- Ty RNA levels determine the spectrum of retrotransposition events that activate gene expression in Saccharomyces cerevisiae.Molecular & general genetics : MGG · 1990Article
- DNA damage activates transcription and transposition of yeast Ty retrotransposons.Molecular & general genetics : MGG · 1989Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transposition of Ty elements in the yeast Saccharomyces cerevisiae occurs through an RNA intermediate. Although Ty RNA accounts for 5 to 10% of the total polyadenylated RNA in a haploid cell, the transposition frequency is only 10(-7) to 10(-8) per gene. To determine whether Ty elements native to the yeast genome are transpositionally competent, two elements were fused to the GAL1 promoter and tested for their ability to transpose. These native elements, Ty1-588 and Ty2-117, transposed at high levels when the GAL1 promoter was induced. Three Ty's identified as spontaneous transpositions in specific target genes were also tested. Of these three, Ty2-917 and the previously characterized element Ty1-H3 were shown to be transpositionally competent. The third element, Ty1-H1, was transposition defective. In addition, we marked the chromosomal copy of Ty1-588 with the NEO gene and demonstrated that Ty1-588NEO was actively transcribed in yeast cells. Ty1-588NEO transcription was regulated by the SPT3 and MAT loci in the same manner as that observed for Ty's collectively. These results indicate that the yeast genome contains functional Ty elements. The presence of a transpositionally competent, actively transcribed element suggests that regulation of Ty transposition occurs at a posttranscriptional level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.