Evidence map›Paper›PMID 28516946›Full record

ArticleNature communications2017

Ccl2/Ccr2 signalling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing.

Mathieu Castela, Dany Nassar, Maria Sbeih, Marie Jachiet, Zhe Wang, Selim Aractingi

Abstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mathieu CastelaINSERM UMRS_938, Saint-Antoine Research Center, 27, rue de Chaligny, Paris 75012, France.ORCID 0000-0001-8745-9583
Dany NassarUniversité Paris 5 Descartes, 12, rue de l'Ecole de Médecine, Paris 75006, France.
Maria SbeihINSERM UMRS_938, Saint-Antoine Research Center, 27, rue de Chaligny, Paris 75012, France.
Marie JachietINSERM UMRS_938, Saint-Antoine Research Center, 27, rue de Chaligny, Paris 75012, France.
Zhe WangINSERM UMRS_938, Saint-Antoine Research Center, 27, rue de Chaligny, Paris 75012, France.
Selim AractingiINSERM UMRS_938, Saint-Antoine Research Center, 27, rue de Chaligny, Paris 75012, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foetal microchimeric cells (FMCs) traffic into maternal circulation during pregnancy and persist for decades after delivery. Upon maternal injury, FMCs migrate to affected sites where they participate in tissue healing. However, the specific signals regulating the trafficking of FMCs to injury sites had to be identified. Here we report that, in mice, a subset of FMCs implicated in tissue repair displays CD11b

Indexed as

Neovascularization, PhysiologicAnimalsAntigens, CD34CD11b AntigenChemokine CCL2Chemokine CXCL1Endothelial Progenitor CellsFemaleFetusGene Expression RegulationMicePlacental CirculationPlatelet Endothelial Cell Adhesion Molecule-1PregnancyReceptors, CCR2Signal TransductionAntigens, CD34Ccl2 protein, mouseCcr2 protein, mouseCD11b AntigenChemokine CCL2Chemokine CXCL1Cxcl1 protein, mousePecam1 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1Receptors, CCR2

Identifiers

PMID28516946
PMCPMC5477505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.