Evidence map›Paper›PMID 28516866›Full record

ArticleEmerging infectious diseases2017

Invasive Serotype 35B Pneumococci Including an Expanding Serotype Switch Lineage, United States, 2015-2016.

Sopio Chochua, Benjamin J Metcalf, Zhongya Li, Hollis Walker, Theresa Tran, Lesley McGee, Bernard Beall

Erratum issuedAbstract read
In one paragraph

Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Human vaccines & immunotherapeutics · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Bacteriological characteristics and changes ofEpidemiology and infection · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. AMicrobial genomics · 2022
    Article
  14. Epidemiology of non-vaccine serotypes ofHuman vaccines & immunotherapeutics · 2021
    Review
  15. Microbial genomics · 2021
    Article
  16. Article
  17. Multistate population and whole genome sequence-based strain surveillance of invasive pneumococci recovered in the USA during 2017.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sopio Chochua
Benjamin J Metcalf
Zhongya Li
Hollis Walker
Theresa Tran
Lesley McGee
Bernard Beall

Funding

CDC HHSWellcome Trust
6 · The paper itself

Abstract

We used whole-genome sequencing to characterize 199 nonvaccine serotype 35B pneumococcal strains that caused invasive pneumococcal disease (IPD) in the United States during 2015-2016 and related these findings to previous serotype 35B IPD data obtained by Active Bacterial Core surveillance. Penicillin-nonsusceptible 35B IPD increased during post-pneumococcal 7-valent conjugate vaccine years (2001-2009) and increased further after implementation of pneumococcal 13-valent conjugate vaccine in 2010. This increase was caused primarily by the 35B/sequence type (ST) 558 lineage. 35B/ST558 and vaccine serotype 9V/ST156 lineages were implicated as cps35B donor and recipient, respectively, for a single capsular switch event that generated emergent 35B/ST156 progeny in 6 states during 2015-2016. Three additional capsular switch 35B variants were identified, 2 of which also involved 35B/ST558 as cps35B donor. Spread of 35B/ST156 is of concern in view of past global predominance of pathogenic ST156 vaccine serotype strains. Protection against serotype 35B should be considered in next-generation pneumococcal vaccines.

Indexed as

GenotypeSerogroupGene Expression Regulation, BacterialGenome, BacterialHumansPenicillin ResistancePneumococcal InfectionsSerotypingStreptococcus pneumoniaeUnited Statesbacteriainvasive pneumococcal diseasepenicillin-binding protein typespneumococcal 13-valent conjugate vaccinepneumococcal 7-valent conjugate vaccinepneumococcal conjugatepneumococcirecombinationrespiratory infectionsserotype 35Bserotype expansionserotype switchsurveillanceswitch lineageUnited Statesvaccines

Identifiers

PMID28516866
PMCPMC5443455

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.