ArticleJournal of neurology2017
Burden of herpes simplex virus encephalitis in the United States.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review.Journal of neuroinflammation · 2019Pooled it
- Systematic review of rehabilitation intervention outcomes of adult and paediatric patients with infectious encephalitis.BMJ open · 2018Pooled it
- Article
- Article
- Herpes Encephalitis as a Differential Diagnosis of Atypical Intracerebral Hemorrhage: A Case Series and Systematic Review.Life (Basel, Switzerland) · 2026Article
- A Diagnostic Challenge: From Suspected Ischemic Stroke to Confirmed Herpetic Encephalitis.Clinical case reports · 2026Article
- Diagnostic Value of the "Insular Knife-Cut" Sign in Patients With Suspected Herpes Simplex Virus Encephalitis.European journal of neurology · 2025Article
- HSV-1 virions and related particles: biogenesis and implications in the infection.Journal of virology · 2025Review
- Article
- Herpes Simplex Encephalitis Complicated With Vasculitis in a Young Male: A Case Report.Clinical case reports · 2024Article
- Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality.Infection · 2024Article
- Specific clinical and radiological characteristics of anti-NMDA receptor autoimmune encephalitis following herpes encephalitis.Journal of neurology · 2024Article
- Viral Infection and Ischemic Stroke: Emerging Trends and Mechanistic Insights.Journal of the American Heart Association · 2024Review
- Recurrent encephalitis and stroke following cessation of acyclovir prophylaxis in a patient with neonatal herpes simplex virus withAnnals of the Child Neurology Society · 2024Article
- Herpes Simplex Virus Encephalitis in Patients With Autoimmune Conditions or Exposure to Immunomodulatory Medications.Neurology · 2024Article
- New Directions in Infection-Associated Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2024Review
- Temporal lobe hemorrhage as a complication of HSV encephalitis: a case report.Clinical case reports · 2023Article
- Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis.Annals of intensive care · 2023Article
- MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST.PLoS pathogens · 2022Article
- Etiological Analysis of Viral Encephalitis in Children in Zhejiang Province from 2018 to 2019.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpes simplex virus encephalitis (HSVE) is a disease of public health concern, but its burden on the healthcare of United States has not been adequately assessed recently. We aimed to define the incidence, complications and outcomes of HSVE in the recent decade by analyzing data from a nationally representative database. Healthcare Cost and Utilization Project databases were utilized to identify patients with primary discharge diagnosis of HSVE. Annual hospitalization rate was estimated and several preselected inpatient complications were identified. Regression analyses were used to identify mortality predictors. Key epidemiological factors were compared with those from other countries. Total 4871 patients of HSVE were included in our study. The annual hospitalization rate was 10.3 ± 2.2 cases/million in neonates, 2.4 ± 0.3 cases/million in children and 6.4 ± 0.4 cases/million in adults. Median age was 57 years and male:female incidence ratio was 1:1. Rates of some central nervous system complications were seizures (38.4%), status epilepticus (5.5%), acute respiratory failure (20.1%), ischemic stroke (5.6%) and intracranial hemorrhage (2.7%), all of which were significantly associated with mortality. In-hospital mortality in neonates, children and adults were 6.9, 1.2 and 7.7%, respectively. HSVE still remains a potentially lethal infectious disease with high morbidity and mortality. Most recent epidemiological data in this study may help understanding this public health disease, and the patient outcome data may have prognostic significance.
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Registered trials
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