ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017
Duodenal and Ampullary Carcinoid Tumors: Size Predicts Necessity for Lymphadenectomy.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors for lymph node metastasis in duodenal neuroendocrine tumors: a systematic review and meta-analysis.Journal of gastroenterology · 2025Pooled it
- [Duodenal neuroendocrine neoplasms (NEN): update on endoscopic and surgical management].Chirurgie (Heidelberg, Germany) · 2026Review
- Primary tumor size as a prognostic factor in duodenal neuroendocrine neoplasms ≤20 mm: a population-based SEER analysis.Endocrine oncology (Bristol, England) · 2026Article
- Nonexposure full-thickness resection in a laparoscopic-endoscopic approach as a hybrid technique for nonampullary duodenal neuroendocrine tumor.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025Article
- Prediction of tumor recurrence after surgical resection of ampullary adenocarcinoma using magnetic resonance imaging.European radiology · 2024Article
- Duodenal neuroendocrine tumor after bilateral breast cancer with type 1 neurofibromatosis: a case report.Surgical case reports · 2024Article
- Surgical and Endoscopic Resection of Duodenal Neuroendocrine Tumors Have Similar Disease-Specific Survival Outcome.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Role of Advanced Gastrointestinal Endoscopy in the Comprehensive Management of Neuroendocrine Neoplasms.Cancers · 2023Review
- Article
- Neuroendocrine tumor of the ampulla of Vater treated with endoscopic papillectomy: A case report.DEN open · 2023Article
- Development and Validation of Prognostic Nomograms for Periampullary Neuroendocrine Neoplasms: A SEER Database Analysis.Current oncology (Toronto, Ont.) · 2022Article
- Diagnostic features and management options for duodenal neuroendocrine neoplasms: a retrospective, multi-centre study.Scientific reports · 2022Article
- Survival comparison between endoscopic and surgical resection for non-ampullary duodenal neuroendocrine tumor (1-2 cm).Scientific reports · 2022Article
- Current Oncologic Standards for Surgery of Small Bowel Cancers.Journal of gastrointestinal cancer · 2022Article
- Ampullary Neuroendocrine Neoplasms: Identification of Prognostic Factors in a Multicentric Series of 119 Cases.Endocrine pathology · 2022Article
- How to Select Patients Affected by Neuroendocrine Neoplasms for Surgery.Current oncology reports · 2022Review
- Management of Duodenal Neuroendocrine Tumors: Surgical versus Endoscopic Mucosal Resection.Annals of surgical oncology · 2022Article
- Risk of preoperative understaging of duodenal neuroendocrine neoplasms: a plea for caution in the treatment strategy.Journal of endocrinological investigation · 2021Article
- Clip band ligation ablation.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2021Article
- Endoscopic papillectomy for an ampullary neuroendocrine tumor.Clinical journal of gastroenterology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnlike other neuroendocrine tumors of the gastrointestinal tract, management of duodenal and periampullary carcinoids remains controversial. We aimed to determine the metastatic potential and optimal choice of therapy for these neoplasms.
methodsA retrospective review of all patients treated at the Johns Hopkins Hospital between 1996 and 2012 was conducted. Clinicopathologic factors associated with lymph nodal involvement and clinical outcomes were evaluated.
resultsA total of 101 patients were identified. Eighty (79.2%) tumors arose from the duodenum and 21 (20.8%) from the periampullary area. Thirty-five (34.7%) patients underwent pancreaticoduodenectomy (PD), 12 (11.9%) local resection, 38 (37.6%) endoscopic excision, and 16 (15.8%) patients harbored incidental tumors identified in the specimen after PD for another indication. Lymph node (LN) pathologic evaluation was done in 56 patients, among which 27 (48%) had positive LN. Specifically, LN positivity (LN+) for tumors <1 cm in size was 4.5% (1/22), for tumors 1-2 cm 72% (13/18), and for tumors >2 cm 81% (13/16). Tumor size was the only factor associated with LN+ (p = 0.029).
conclusionLymph nodal involvement is common for duodenal and periampullary carcinoid tumors, particularly among those >1 cm in size; therefore, resection with lymphadenectomyfor these larger tumors is recommended.
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