ReviewNeuroscience bulletin2017
Region-Specific Iron Measured by MRI as a Biomarker for Parkinson's Disease.
Review in Neuroscience bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Interpretable machine learning for Parkinson's disease diagnosis, staging, and biological mechanism exploration: a multicenter analysis.BioData mining · 2026Article
- Review
- Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson's disease.European radiology · 2024Article
- Review
- A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson's disease: a brain radiomics study.Neural regeneration research · 2022Article
- Iron- and Neuromelanin-Weighted Neuroimaging to Study Mitochondrial Dysfunction in Patients with Parkinson's Disease.International journal of molecular sciences · 2022Review
- The protective role of cigarette smoking against Parkinson's disease via moderation of the interaction between iron deposition in the nigrostriatal pathway and clinical symptoms.Quantitative imaging in medicine and surgery · 2022Article
- [MRI Findings in Parkinson's Disease: Radiologic Assessment of Nigrostriatal Degeneration].Taehan Yongsang Uihakhoe chi · 2022Review
- Stereotactic Surgery of Parkinson's Disease with Magnetic Resonance Imaging under Three-Dimensional Mark Point Positioning Algorithm.Contrast media & molecular imaging · 2022Article
- Nigral Iron Deposition Influences Disease Severity by Modulating the Effect of Parkinson's Disease on Brain Networks.Journal of Parkinson's disease · 2022Article
- Subcortical Iron Accumulation Pattern May Predict Neuropsychological Outcomes After Subthalamic Nucleus Deep Brain Stimulation: A Pilot Study.Journal of Parkinson's disease · 2022Article
- Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease.Brain structure & function · 2021Article
- Elemental quantification and analysis of structural abnormalities in neurons from Parkinson's-diseased brains by X-ray fluorescence microscopy and diffraction.Biomedical optics express · 2020Article
- Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra.BMC neurology · 2020Article
- MRI biomarkers of motor and non-motor symptoms in Parkinson's disease.Parkinsonism & related disorders · 2020Review
- L-type Calcium Channels are Involved in Iron-induced Neurotoxicity in Primary Cultured Ventral Mesencephalon Neurons of Rats.Neuroscience bulletin · 2020Article
- Biomarkers for Parkinson's Disease: How Good Are They?Neuroscience bulletin · 2020Review
- Modern Brainstem MRI Techniques for the Diagnosis of Parkinson's Disease and Parkinsonisms.Frontiers in neurology · 2020Review
- Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease.Neurobiology of aging · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of sensitive and specific biomarkers for Parkinson's disease (PD) poses an important clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD. However, questions remain, such as the relationship between nigral iron and clinical indices of PD (motor impairment or disease duration). Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging (MRI) allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics: the technological development of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.