Evidence map›Paper›PMID 28516165›Full record

ArticleBioengineering & translational medicine2017

Host- and pathogen-derived adjuvant coatings on protein nanoparticle vaccines.

Timothy Z Chang, Ishatou Diambou, Jong Rok Kim, Baozhong Wang, Julie A Champion

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  4. Protein and Peptide Nanocluster Vaccines.Current topics in microbiology and immunology · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Phage display as a tool for vaccine and immunotherapy development.Bioengineering & translational medicine · 2020
    Review
  9. Article
  10. "Locked" cancer cells are more sensitive to chemotherapy.Bioengineering & translational medicine · 2019
    Article
  11. A health concern regarding the protein corona, aggregation and disaggregation.Biochimica et biophysica acta. General subjects · 2019
    Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Timothy Z ChangSchool of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta GA 30332.
Ishatou DiambouSchool of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta GA 30332.
Jong Rok KimInstitute for Biomedical Sciences Georgia State University Atlanta GA 30332.
Baozhong WangInstitute for Biomedical Sciences Georgia State University Atlanta GA 30332.
Julie A ChampionSchool of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta GA 30332.
Georgia Institute of Technology · USGeorgia State University · US

Funding

Novel Influenza nano vaccines for broad cross protectionR01AI101047 · NIAID · GEORGIA STATE UNIVERSITY · PI WANG, BAOZHONG · 2012 to 2023
$6.1M
NIAID NIH HHS R01 AI101047
6 · The paper itself

Abstract

Nanoparticulate and molecular adjuvants have shown great efficacy in enhancing immune responses, and the immunogenic vaccines of the future will most likely contain both. To investigate the immunostimulatory effects of molecular adjuvants on nanoparticle vaccines, we have designed ovalbumin (OVA) protein nanoparticles coated with two different adjuvants-flagellin (FliC) and immunoglobulin M (IgM). These proteins, derived from

Indexed as

adjuvantaffinity maturationcoatingflagellinimmunoglobulin Mnanoparticlevaccine

Identifiers

PMID28516165
PMCPMC5412930
OpenAlexW2562146097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.