Evidence map›Paper›PMID 28516113›Full record

ArticleBio-protocol2016

Pit Assay to Measure the Bone Resorptive Activity of Bone Marrow-derived Osteoclasts.

Alexander Vesprey, Wentian Yang

Abstract read
In one paragraph

Article in Bio-protocol, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Osteocytes Produces RANKL Via Wnt-TGFβ Signaling Axis for Osteoclastogenesis.International journal of biological sciences · 2025
    Article
  7. Heparan sulfate selectively inhibits the collagenase activity of cathepsin K.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  8. Article
  9. Article
  10. Molecular medicine reports · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Pathogens (Basel, Switzerland) · 2022
    Article
  15. Mesenchymal Stem Cell and Monocyte Co-cultures.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander VespreyDepartment of Orthopaedics, Alpert Medical School and Rhode Island Hospital, Brown University, Providence, USA.
Wentian YangDepartment of Orthopaedics, Alpert Medical School and Rhode Island Hospital, Brown University, Providence, USA.

Funding

Stem Cell Biology: New Directions in Clinical and Basic ResearchP20GM103468 · NIGMS · RHODE ISLAND HOSPITAL · PI QUESENBERRY, PETER J. · 2012 to 2013
$4.5M
Role of PTPN11 in Cartilage Stem Cells and TumorigenesisR01AR066746 · NIAMS · RHODE ISLAND HOSPITAL · PI YANG, WENTIAN · 2015 to 2019
$1.8M
Shp2 in Osteoclastogenesis and Bone RemodelingR21AR057156 · NIAMS · RHODE ISLAND HOSPITAL · PI YANG, WENTIAN · 2009 to 2010
$378k
NIAMS NIH HHS R01 AR066746NIAMS NIH HHS R21 AR057156NIGMS NIH HHS P20 GM103468
6 · The paper itself

Abstract

Although it is possible to use a tartrate-resistant acid phosphatase (TRAP) stain to assist in identifying osteoclasts, a separate method is needed to determine the bone resorption activity of osteoclasts. Since osteoclasts leave "pits" after bone matrix resorption (Charles

Identifiers

PMID28516113
PMCPMC5431589

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.