ArticleNeuroImage. Clinical2017
Synergistic but independent: The role of corticospinal and alternate motor fibers for residual motor output after stroke.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Transcranial direct current stimulation for gait recovery following stroke: A systematic review of current literature and beyond.Frontiers in neurology · 2022Pooled it
- Diffusion tensor imaging and gray matter volumetry to evaluate cerebral remodeling processes after a pure motor stroke: a longitudinal study.Journal of neurology · 2024Trial
- Test-retest reliability and minimal detectable change of corticospinal tract integrity in chronic stroke.Human brain mapping · 2020Trial
- Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage.Annals of clinical and translational neurology · 2026Article
- Reopening Motor Learning Windows: Targeted Re-Engagement of Latent Pathways via Non-Invasive Neuromodulation.Life (Basel, Switzerland) · 2026Review
- Altered Functional Connectivity Between Cortical Premotor Areas and the Spinal Cord in Chronic Stroke.Stroke · 2025Article
- Microstructure of the residual corticofugal projection from primary motor cortex in chronic stroke.Brain communications · 2025Article
- Moving toward elucidating alternative motor pathway structures post-stroke: the value of spinal cord neuroimaging.Frontiers in neurology · 2024Review
- Compensatory increase in ipsilesional supplementary motor area and premotor connectivity is associated with greater gait impairments: a personalized fMRI analysis in chronic stroke.Frontiers in human neuroscience · 2024Article
- Assessment of corticospinal tract damage and cytokines response in early and late stages of acute unilateral brainstem infarction patients.Frontiers in immunology · 2024Article
- Applicability of automated tractography during acute care stroke rehabilitation.Journal of physical therapy science · 2023Article
- The role of corticospinal and extrapyramidal pathways in motor impairment after stroke.Brain communications · 2023Article
- Connectomic insight into unique stroke patient recovery after rTMS treatment.Frontiers in neurology · 2023Article
- Prediction of post-stroke motor recovery benefits from measures of sub-acute widespread network damages.Brain communications · 2023Article
- Dynamic Relationship Between Interhemispheric Functional Connectivity and Corticospinal Tract Changing Pattern After Subcortical Stroke.Frontiers in aging neuroscience · 2022Article
- The relationship between motor pathway damage and flexion-extension patterns of muscle co-excitation during walking.Frontiers in neurology · 2022Article
- Mapping the corticoreticular pathway from cortex-wide anterograde axonal tracing in the mouse.Journal of neuroscience research · 2021Article
- Functional redundancy of the premotor network in hemispherotomy patients.Annals of clinical and translational neurology · 2021Article
- The structural connectome and motor recovery after stroke: predicting natural recovery.Brain : a journal of neurology · 2021Article
- Comparison of corticospinal tract integrity measures extracted from standard versus native space in chronic stroke.Journal of neuroscience methods · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain imaging has shown that not only the cortico-spinal tract (CST), but also alternate corticofugal motor fibers (aMF), such as the cortico-rubro-spinal and cortico-reticulo-spinal tract, influence residual motor output after stroke. So far, studies mainly have investigated each tract separately. A combined analysis of CST and aMF with assessment of their interactive role, i.e., that structural integrity of one tract influences the functional role of the structural integrity of the other, is pending.
methods39 late subacute stroke patients (aged 59.4 ± 12.0 years, 100 ± 11 days after stroke) were included. Probabilistic tractography was used to reconstruct CST and aMF. Fractional anisotropy (FA) was calculated as a measure of microstructural integrity. Multiple-linear-regression analysis was used to associate tract-related FA with residual motor output and to determine interactions between CST and aMF.
resultsBoth CST (coefficient = 3.93,
conclusionsThe structural states of the CST and also - to a smaller degree - of the aMF correlate with residual motor output in late subacute stroke patients. Based on this statistical modeling with all inherent limitations, the novel finding of an absence of a significant interaction between both tracts in regard of their functional role, suggests that both corticofugal pathways act synergistically but largely independently. These findings add to the understanding of the functional role of different corticofugal motor fibers and their interactions for motor output after stroke.
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