Evidence map›Paper›PMID 28515963›Full record

ArticleJournal of AIDS & clinical research2017

Eliminating Racial/Ethnic Disparities in AIDS Clinical Trials in the United States: A Qualitative Exploration of an Efficacious Social/Behavioral Intervention.

Amanda Ritchie, Marya Viorst Gwadz, David Perlman, Rebecca De Guzman, Noelle R Leonard, Charles M Cleland

Open access · hybridAbstract read
In one paragraph

Article in Journal of AIDS & clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amanda RitchieCenter for Drug Use and HIV Research, Rory Meyers College of Nursing, New York University, New York, NY, USA.
Marya Viorst GwadzCenter for Drug Use and HIV Research, Rory Meyers College of Nursing, New York University, New York, NY, USA.
David PerlmanDepartment of Infectious Diseases, Mount Sinai Health Systems, New York, NY, USA.
Rebecca De GuzmanPublic Health Institute, Oakland, CA, USA.
Noelle R LeonardCenter for Drug Use and HIV Research, Rory Meyers College of Nursing, New York University, New York, NY, USA.
Charles M ClelandCenter for Drug Use and HIV Research, Rory Meyers College of Nursing, New York University, New York, NY, USA.
New York University · USPublic Health Institute · US

Funding

Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
Peer-Driven Intervention to Enroll Minorities/Women in HIV/AIDS Clinical TrialsR01AI070005 · NIAID · NEW YORK UNIVERSITY · PI GWADZ, MARYA · 2007 to 2010
$2.8M
NIAID NIH HHS R01 AI070005NIDA NIH HHS P30 DA011041
6 · The paper itself

Abstract

backgroundAfrican American/Black and Hispanic persons living with HIV (AABH-PLWH) are under-represented in AIDS clinical trials (ACTs) in the United States. Barriers AABH-PLWH experience to ACTs are multi-faceted, including distrust of medical research, low levels of knowledge, unsupportive social norms, lack of referral, and challenges navigating ACT systems. In past research we found a multi-component peer-driven intervention was efficacious in boosting rates of screening for/enrollment into ACTs. The present qualitative study seeks to understand AABH-PLWH's perspectives on which specific intervention features or components had utility. Interventions features explored included structural elements (e.g., small group sessions, individual sessions on the ACT research unit); approaches (e.g., Motivational Interviewing); and specific components (e.g., small-group discussion of historical and cultural factors reducing participation among AABH-PLWH).

methodsA total of 37 AABH-PLWH (mean age 50.6 years, SD=7.5 years; 48.6% female; 62.2% African American/Black, 27.0% Hispanic) were purposively selected from a larger study for in-depth interviews, which were audio-recorded, transcribed verbatim, and analyzed using systematic content analysis.

resultsWe found the intervention improved knowledge and positive attitudes toward ACTs, and triggered social-level facilitators such as altruism and more positive social norms. Discussions of cultural/historical barriers to ACTs associated with race/ethnicity had utility. Holding a session on the ACT research unit reduced fear and increased motivation. Results highlighted the value of Motivational Interviewing, and several components were perceived as less useful (e.g., involving social network members in ACT decisions).

conclusionFindings can inform future intervention designs to address racial/ethnic disparities in ACTs and have implications for trials of other conditions where racial/ethnic disparities persist.

Indexed as

African AmericanAIDS clinical trialsHealth disparitiesHispanicHIVMedical distrustQualitativeRace

Identifiers

PMID28515963
PMCPMC5431576
OpenAlexW2587054003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.