Evidence map›Paper›PMID 28515902›Full record

ArticleAntimicrobial resistance and infection control2017

Sites of colonization in hospitalized patients with infections caused by extended-spectrum beta-lactamase organisms: a prospective cohort study.

Zeina A Kanafani, Sukayna M Fadlallah, Sarah Assaf, Khalil Anouti, Kohar Annie B Kissoyan, Jad Sfeir, Tamara Nawar, Mohamad Yasmin, Ghassan M Matar

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Article in Antimicrobial resistance and infection control, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zeina A KanafaniDepartment of Internal Medicine, American University of Beirut, PO Box 11-0236/11D, Cairo Street, Riad El Solh, Beirut, 1107 2020 Lebanon.
Sukayna M FadlallahDepartment of Experimental Pathology, Immunology and Microbiology, American University of Beirut, Beirut, Lebanon.
Sarah AssafDepartment of Internal Medicine, American University of Beirut, PO Box 11-0236/11D, Cairo Street, Riad El Solh, Beirut, 1107 2020 Lebanon.
Khalil AnoutiDepartment of Internal Medicine, American University of Beirut, PO Box 11-0236/11D, Cairo Street, Riad El Solh, Beirut, 1107 2020 Lebanon.
Kohar Annie B KissoyanDepartment of Experimental Pathology, Immunology and Microbiology, American University of Beirut, Beirut, Lebanon.
Jad SfeirDepartment of Internal Medicine, American University of Beirut, PO Box 11-0236/11D, Cairo Street, Riad El Solh, Beirut, 1107 2020 Lebanon.
Tamara NawarDepartment of Internal Medicine, American University of Beirut, PO Box 11-0236/11D, Cairo Street, Riad El Solh, Beirut, 1107 2020 Lebanon.
Mohamad YasminDepartment of Internal Medicine, American University of Beirut, PO Box 11-0236/11D, Cairo Street, Riad El Solh, Beirut, 1107 2020 Lebanon.
Ghassan M MatarDepartment of Experimental Pathology, Immunology and Microbiology, American University of Beirut, Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to determine whether patients infected with extended-spectrum beta-lactamase (ESBL)-producing organisms are colonized at multiple body sites.

methodsThis was a prospective cohort study at a tertiary care center in Beirut, Lebanon. Hospitalized patients with infections caused by ESBL-producing organisms were included. Cultures were obtained from the primary site of infection as well as from other sites (skin, nasopharynx, urine, rectum). Molecular analysis was performed on isolates to determine clonal relatedness.

resultsOne hundred patients were included in the study. Only 22 patients had positive cultures from sites other than the primary site of infection. The most common ESBL gene was CTX-M-15 followed by TEM-1. In 11 of 22 patients, isolates collected from the same patient were 100% genetically related, while in the remaining patients, genomic relatedness ranged from 42.9% to 97.1%.

conclusionsColonization at sites other than the primary site of infection was not common among our patient population infected with ESBL-producing organisms. The dynamics of transmission of these bacterial strains should be studied in further prospective studies to determine the value of routine active surveillance and the need for expanded precautions in infected and colonized patients.

Indexed as

Antibiotic resistanceColonizationExtended spectrum beta-lactamasesMolecular analysisScreening

Identifiers

PMID28515902
PMCPMC5433240

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