ArticleWorld journal of cardiology2017
QT prolongation is associated with increased mortality in end stage liver disease.
Article in World journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Propofol prevents further prolongation of QT interval during liver transplantation.Scientific reports · 2022Trial
- Article
- Cirrhotic cardiomyopathy: pathophysiology, assessment, and implications for liver transplantation.Therapeutic advances in gastroenterology · 2026Review
- Sudden cardiac death associated with fatty liver disease.International journal of cardiology. Heart & vasculature · 2025Article
- Cardiomyopathy in cirrhosis: From pathophysiology to clinical care.JHEP reports : innovation in hepatology · 2024Review
- Corrected QT interval in cirrhosis: A systematic review and meta-analysis.World journal of hepatology · 2023Article
- Prolonged QT Interval in Cirrhosis: Twisting Time?Gut and liver · 2022Review
- Cardiac risk stratification of the liver transplant candidate: A comprehensive review.World journal of transplantation · 2022Review
- The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.BMC cardiovascular disorders · 2022Article
- QTc interval prolongation in the patients with primary biliary cholangitis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Article
- β-blockers in advanced cirrhosis: More friend than enemy.Clinical and molecular hepatology · 2021Review
- Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications.Nature reviews. Cardiology · 2021Review
- What Every Intensivist should Know about Impairment of Cardiac Function and Arrhythmias in Liver Disease Patients: A Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Review
- Mortality and morbidity in patients with atrial fibrillation and liver cirrhosis.World journal of cardiology · 2020Article
- QTc prolongation in patients of cirrhosis and its relation with disease severity: An observational study from a rural teaching hospital.Journal of family medicine and primary care · 2020Article
- An Observational Study of QTc Prolongation in Critically Ill Patients: Identification of Incidence and Predictors.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Review
- Myocardial contractile dispersion: A new marker for the severity of cirrhosis?Journal of cardiovascular and thoracic research · 2019Article
- Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity.World journal of gastrointestinal pathophysiology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the prevalence of QT prolongation in a large series of end stage liver disease (ESLD) patients and its association to clinical variables and mortality.
methodsThe QT interval was measured and corrected for heart rate for each patient, with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females. Multiple clinical variables were evaluated including sex, age, serum sodium, international normalized ratio, creatinine, total bilirubin, beta-blocker use, Model for End-Stage Liver Disease (MELD), MELD-Na, and etiology of liver disease.
resultsAmong 406 ESLD patients analyzed, 207 (51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender (OR = 3.04, 95%CI: 2.01-4.60,
conclusionQT prolongation was commonly encountered in an ESLD population, especially in males, and served as a strong independent marker for increased mortality in ESLD patients.
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