ArticleFrontiers in neurology2017
Disrupted Structural and Functional Networks and Their Correlation with Alertness in Right Temporal Lobe Epilepsy: A Graph Theory Study.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Volumetric and functional connectivity alterations of the thalamus and thalamic nuclei groups in drug-resistant focal epilepsy: A 7T MRI study.Neuroradiology · 2026Article
- Structural and effective brain connectivity in focal epilepsy.Neuroimage. Reports · 2025Article
- Abnormal white matter structural network topological property in patients with temporal lobe epilepsy.CNS neuroscience & therapeutics · 2024Article
- Brain functional network changes in patients with juvenile myoclonic epilepsy: a study based on graph theory and Granger causality analysis.Frontiers in neuroscience · 2024Article
- Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Functional connectivity alterations in traumatic brain injury patients with late seizures.Neurobiology of disease · 2023Article
- Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients.Frontiers in human neuroscience · 2023Article
- Topological properties and connectivity patterns in brain networks of patients with refractory epilepsy combined with intracranial electrical stimulation.Frontiers in neuroscience · 2023Article
- A Comparative Analysis of White Matter Structural Networks on SCLC Patients After Chemotherapy.Brain topography · 2022Article
- A study of brain functional network and alertness changes in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.BMC neurology · 2022Article
- Brain Network Alterations in Rectal Cancer Survivors With Depression Tendency: Evaluation With Multimodal Magnetic Resonance Imaging.Frontiers in neurology · 2022Article
- Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.Frontiers in neuroscience · 2022Article
- Alterations of core structural network connectome associated with suicidal ideation in major depressive disorder patients.Translational psychiatry · 2021Article
- Altered EEG Brain Networks in Patients with Acute Peripheral Herpes Zoster.Journal of pain research · 2021Article
- Multiscale dynamic mean field (MDMF) model relates resting-state brain dynamics with local cortical excitatory-inhibitory neurotransmitter homeostasis.Network neuroscience (Cambridge, Mass.) · 2021Article
- Comparison of topological properties of functional brain networks with graph theory in temporal lobe epilepsy with different duration of disease.Annals of translational medicine · 2020Article
- Altered White Matter Structural Network in Frontal and Temporal Lobe Epilepsy: A Graph-Theoretical Study.Frontiers in neurology · 2020Article
- Understanding white matter structural connectivity differences between cognitively impaired and nonimpaired active professional fighters.Human brain mapping · 2019Article
- Resting-state brain entropy in right temporal lobe epilepsy and its relationship with alertness.Brain and behavior · 2019Article
- Models of Network Spread and Network Degeneration in Brain Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
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Authors and funding
5 authors.
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Abstract
Previous studies have shown that temporal lobe epilepsy (TLE) involves abnormal structural or functional connectivity in specific brain areas. However, limited comprehensive studies have been conducted on TLE associated changes in the topological organization of structural and functional networks. Additionally, epilepsy is associated with impairment in alertness, a fundamental component of attention. In this study, structural networks were constructed using diffusion tensor imaging tractography, and functional networks were obtained from resting-state functional MRI temporal series correlations in 20 right temporal lobe epilepsy (rTLE) patients and 19 healthy controls. Global network properties were computed by graph theoretical analysis, and correlations were assessed between global network properties and alertness. The results from these analyses showed that rTLE patients exhibit abnormal small-world attributes in structural and functional networks. Structural networks shifted toward more regular attributes, but functional networks trended toward more random attributes. After controlling for the influence of the disease duration, negative correlations were found between alertness, small-worldness, and the cluster coefficient. However, alertness did not correlate with either the characteristic path length or global efficiency in rTLE patients. Our findings show that disruptions of the topological construction of brain structural and functional networks as well as small-world property bias are associated with deficits in alertness in rTLE patients. These data suggest that reorganization of brain networks develops as a mechanism to compensate for altered structural and functional brain function during disease progression.
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