ReviewThrombosis journal2017
Perioperative management of patients on direct oral anticoagulants.
Review in Thrombosis journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04852406 (Effect of Protocol-based Management on Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Protocol-based Management on Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy: a Pragmatic Interventional Study
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Interrupted versus uninterrupted anticoagulation for cardiac rhythm management device insertion.The Cochrane database of systematic reviews · 2025Pooled it
- Direct oral anticoagulant safety during breastfeeding: a narrative review.European journal of clinical pharmacology · 2021Pooled it
- Perioperative Management of Patients Receiving Interventional Techniques and Antiplatelet and Anticoagulant Therapy: A Balancing Act.Current pain and headache reports · 2025Review
- The effect of anticoagulation therapy on the surgical outcomes of minimally invasive major gastrointestinal surgery.Surgical endoscopy · 2025Article
- Contemporary approaches in the peri-endoscopic management of antithrombotic agents: current paradigms, challenges, and prognostications.Therapeutic advances in gastroenterology · 2025Review
- Prothrombotic Rebound After Discontinuation of Direct Oral Anticoagulants Therapy: A Systematic Review.Journal of clinical medicine · 2024Review
- Pre-Operative Direct Oral Anticoagulant Level Measurement Reduces Time to Surgery in Hip Fracture Patients.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- Association between direct oral anticoagulant concentrations and clinical outcomes: A systematic review and meta-analysis.Surgery in practice and science · 2023Review
- Early hip fracture surgery is safe for patients on direct oral anticoagulants.OTA international : the open access journal of orthopaedic trauma · 2023Article
- The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review.Thrombosis journal · 2023Review
- Perioperative Anticoagulation in Patients with Cancer.Current oncology reports · 2023Review
- Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation.Research and practice in thrombosis and haemostasis · 2023Article
- SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock.Frontiers in physiology · 2023Review
- Local Tranexamic Acid for Preventing Hemorrhage in Anticoagulated Patients Undergoing Dental and Minor Oral Procedures: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Proactive Risk Assessment through Failure Mode and Effect Analysis (FMEA) for Perioperative Management Model of Oral Anticoagulant Therapy: A Pilot Project.International journal of environmental research and public health · 2022Article
- Improving documentation of anticoagulation and antiplatelet recommendations after outpatientendoscopy.BMJ open quality · 2022Article
- Timing of Surgery for Hip Fracture in Patients on Direct Oral Anti-coagulants: A Population-Based Cohort Study.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Long-Term Medication Adherence Trajectories to Direct Oral Anticoagulants and Clinical Outcomes in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2021Article
- Challenges in Patient Blood Management for Cardiac Surgery: A Narrative Review.Journal of clinical medicine · 2021Review
- Evaluation of the effect of apixaban using a viscoelastic coagulation assay with Russell's viper venom reagent.JA clinical reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for various indications. Each year, 10-15% of patients on oral anticoagulants will undergo an invasive procedure and expert groups have issued several guidelines on perioperative management in such situations. The perioperative guidelines have undergone numerous updates as clinical experience of emergency management has increased and perioperative studies including measurement of residual anticoagulant levels have been published. The high inter-patient variability of DOAC plasma levels has challenged the traditional recommendation that perioperative DOAC interruption should be based only on the elimination half-life of DOACs, especially before invasive procedures carrying a high risk of bleeding. Furthermore, recent publications have highlighted the potential danger of heparin bridging use when DOACs are stopped before an invasive procedure. As antidotes are progressively becoming available to manage severe bleeding or urgent procedures in patients on DOACs, accurate laboratory tests have become the standard to guide their administration and their actions need to be well understood by clinicians. This review aims to provide a systematic approach to managing patients on DOACs, based on recent updates of various perioperative guidance, and highlighting the advantages and limits of recommendations based on pharmacokinetic properties and laboratory tests.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.