ArticleScientific reports2017
Acquisition of virulence factors in livestock-associated MRSA: Lysogenic conversion of CC398 strains by virulence gene-containing phages.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
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- Multiomics analysis of Staphylococcus aureus ST239 strains resistant to virulent Herelleviridae phages.Scientific reports · 2024Article
- Spread of livestock-associated methicillin-resistantOpen veterinary journal · 2024Review
- Newly Isolated Virulent Salmophages for Biocontrol of Multidrug-ResistantInternational journal of molecular sciences · 2023Article
- Whole genome sequence-based analysis ofFrontiers in microbiology · 2023Article
- Fluoroquinolone resistance does not facilitate phage Φ13 integration or excision inAccess microbiology · 2023Article
- A review of new emerging livestock-associated methicillin-resistantVeterinary world · 2023Review
- A review of horses as a source of spreading livestock-associated methicillin-resistantVeterinary world · 2022Review
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- Complete Genome Sequences of the Methicillin-Resistant Strain Staphylococcus aureus 17Gst354 and Its Prophage Staphylococcus Phage vB_StaphS-IVBph354.Microbiology resource announcements · 2021Article
- Prevalence and Characteristics of Multidrug-Resistant Livestock-Associated Methicillin-ResistantAnimals : an open access journal from MDPI · 2021Article
- Proteomic Characterization of Bacteriophage Peptides from the Mastitis ProducerFoods (Basel, Switzerland) · 2021Article
- Diversity and characterization of temperate bacteriophages induced in Pasteurella multocida from different host species.BMC microbiology · 2021Article
- Examination ofViruses · 2021Article
- mMGE: a database for human metagenomic extrachromosomal mobile genetic elements.Nucleic acids research · 2021Article
- Prophage Activation in the Intestine: Insights Into Functions and Possible Applications.Frontiers in microbiology · 2021Review
- Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans.Emerging infectious diseases · 2020Article
- Article
- Genomic Distinctions of LA-MRSA ST398 on Dairy Farms From Different German Federal States With a Low Risk of Severe Human Infections.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus MRSA strains belonging to the clonal complex 398 (CC398) are highly prevalent in livestock and companion animals but may also cause serious infections in humans. CC398 strains in livestock usually do not possess well-known virulence factors that can be frequently found in other MRSA sequence types (ST). Since many staphylococcal virulence genes are residing on the genomes of temperate phages, the question arises why livestock-associated (LA-) CC398 strains are only rarely infected by those phages. We isolated and characterized four temperate phages (P240, P282, P630 and P1105) containing genes of the immune evasion cluster (IEC) and/or for the Panton-Valentine leucocidin (PVL). Sequence analysis of the phage genomes showed that they are closely related to known phages and that the DNA region encoding lysis proteins, virulence factors and the integrase exhibits numerous DNA repeats which may facilitate genomic rearrangements. All phages lysed and lysogenized LA-CC398 strains. Integration of IEC phage P282 was detected at ten sites of the hosts' chromosome. The prophages were stably inherited in LA-CC398 and enterotoxin A, staphylokinase and PVL toxin were produced. The data demonstrate that lysogenic conversion of LA-CC398 strains by virulence-associated phages may occur and that new pathotypes may emerge by this mechanism.
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