ArticleScientific reports2017
Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue.Communications biology · 2025Article
- Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation.Nature communications · 2023Article
- Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice.Communications biology · 2021Article
- Article
- Fiber-specific and whole-muscle LRP130 expression in rested, exercised, and fasted human skeletal muscle.Pflugers Archiv : European journal of physiology · 2020Article
- The Emerging Role of Senescence in Ocular Disease.Oxidative medicine and cellular longevity · 2020Review
- Novel discovery of Averrhoa bilimbi ethanolic leaf extract in the stimulation of brown fat differentiation program in combating diet-induced obesity.BMC complementary and alternative medicine · 2019Article
- Deletion of OGG1 Results in a Differential Signature of Oxidized Purine Base Damage in mtDNA Regions.International journal of molecular sciences · 2019Article
- Mitochondrial Transcriptome Control and Intercompartment Cross-Talk During Plant Development.Cells · 2019Article
- Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.Cell reports · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondrial respiration plays a crucial role in determining the metabolic state of brown adipose tissue (BAT), due to its direct roles in thermogenesis, as well as through additional mechanisms. Here, we show that respiration-dependent retrograde signaling from mitochondria to nucleus contributes to genetic and metabolic reprogramming of BAT. In mouse BAT, ablation of LRPPRC (LRP130), a potent regulator of mitochondrial transcription and respiratory capacity, triggers down-regulation of thermogenic genes, promoting a storage phenotype in BAT. This retrograde regulation functions by inhibiting the recruitment of PPARγ to the regulatory elements of thermogenic genes. Reducing cytosolic Ca
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