ArticleScientific reports2017
High-salt intake negatively regulates fat deposition in mouse.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- The Impact of a Western Diet with High Salt on Metabolic Outcomes in Male C57bl/6J Mice.The journal of nutritional physiology · 2026Article
- Association between serum sodium and the risk of sepsis-related liver injury: a cross-sectional study based on the MIMIC-IV database.BMC infectious diseases · 2025Article
- Multi-omics integration identifies molecular markers and biological pathways for carcass and meat quality traits in Nellore cattle.Scientific reports · 2025Article
- Excess dietary sodium restores electrolyte and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron.American journal of physiology. Renal physiology · 2025Article
- A novel model of cardiovascular-kidney-metabolic syndrome combining unilateral nephrectomy and high-salt-sugar-fat diet in mice.Lab animal · 2024Article
- Intermuscular adipose tissue accumulation is associated with higher tissue sodium in healthy individuals.Physiological reports · 2024Article
- Article
- Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed.Scientific reports · 2023Article
- Astragalus polysaccharide prevents heart failure-induced cachexia by alleviating excessive adipose expenditure in white and brown adipose tissue.Lipids in health and disease · 2023Article
- Alterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet.International journal of molecular sciences · 2022Article
- Effects of sea salt intake on metabolites, steroid hormones, and gut microbiota in rats.PloS one · 2022Article
- Transcriptome Analysis of Multiple Metabolic Tissues in High-Salt Diet-Fed Mice.Frontiers in endocrinology · 2022Article
- High-fat and high-sodium diet induces metabolic dysfunction in the absence of obesity.Obesity (Silver Spring, Md.) · 2021Article
- Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice.Scientific reports · 2021Article
- Article
- Consumption of salt leads to ameliorate symptoms of metabolic disorder and change of gut microbiota.European journal of nutrition · 2020Article
- Alleviation of salt-induced exacerbation of cardiac, renal, and visceral fat pathology in rats with metabolic syndrome by surgical removal of subcutaneous fat.Nutrition & diabetes · 2020Article
- The Effects of Gelatinized Wheat Starch and High Salt Diet on Gut Microbiota and Metabolic Disorder.Nutrients · 2020Article
- GWAS for Meat and Carcass Traits Using Imputed Sequence Level Genotypes in Pooled F2-Designs in Pigs.G3 (Bethesda, Md.) · 2019Article
- Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism.Matrix biology : journal of the International Society for Matrix Biology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-salt (HS) intake contributes to hypertension and cardiopathy, but the effect of HS on fat deposition is controversial. Feed intake, fat mass, the percentage of abdominal fat, heat production, rate of oxygen consumption and the respiratory exchange ratio of mice on a HS diet were significantly decreased (P < 0.01 or 0.05) compared with mice on a normal-salt (NS) diet. An in vitro experiment with differentiating pre-adipocytes showed reduced fat deposition in the presence of high concentrations of NaCl (>0.05 M). Abdominal fat mRNA profiles and protein measurements showed that 5 known genes involved in lipolysis were up-regulated significantly and 9 genes related to lipogenesis were down-regulated in HS mice. Abundant genes and some proteins (ATP2a1, AGT, and ANGPTL4) related to calcium ion metabolism or the renin-angiotensin system (RAS) were differentially expressed between HS and NS mice. Of special interest, CREB1 phosphorylation (S133 and S142), a key factor involved in calcium signaling and other pathways, was up-regulated in HS mice. By IPA analysis, a network mediated by calcium was established providing the molecular mechanisms underlying the negative effect of HS on fat deposition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.