ArticleScientific reports2017
Vascular Remodelling Relates to an Elevated Oscillatory Shear Index and Relative Residence Time in Spontaneously Hypertensive Rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 54 citations in OpenAlex.
- Assessment of biomechanical properties in pulmonary arterial hypertension: a computational fluid dynamics study of the extensive pulmonary arterial tree.BMC pulmonary medicine · 2025Article
- Hemodynamic predictors of rupture in abdominal aortic aneurysms: a case series using computational fluid dynamics.Frontiers in cardiovascular medicine · 2025Article
- Impact of Vein Wall Hyperelasticity and Blood Flow Turbulence on Hemodynamic Parameters in the Inferior Vena Cava with a Filter.Micromachines · 2024Article
- Evaluation of Aortic Diseases Using Four-Dimensional Flow Magnetic Resonance Imaging.Vascular specialist international · 2024Review
- Spatiotemporal analysis of the effects of exercise on the hemodynamics of the aorta in hypertensive rats using fluid-structure interaction simulation.Journal of translational internal medicine · 2024Article
- The Role of Multiple Re-Entry Tears in Type B Aortic Dissection Progression: A Longitudinal Study Using a Controlled Swine Model.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2024Article
- Patient-specific 3DFrontiers in cardiovascular medicine · 2024Article
- Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats.BMC cardiovascular disorders · 2023Article
- Understanding development of jugular bulb stenosis in vein of galen malformations: identifying metrics of complex flow dynamics in the cerebral venous vasculature of infants.Frontiers in physiology · 2023Article
- Non-invasive diagnostics of blockage growth in the descending aorta-computational approach.Medical & biological engineering & computing · 2022Article
- The role of 4-dimensional flow in the assessment of bicuspid aortic valve and its valvulo-aortopathies.The British journal of radiology · 2022Review
- Wall shear stress and relative residence time as potential risk factors for abdominal aortic aneurysms in males: a 4D flow cardiovascular magnetic resonance case-control study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Characterization of hemodynamics in anomalous aortic origin of coronary arteries using patient-specific modeling.Journal of biomechanics · 2022Article
- Cardiovascular deconditioning and impact of artificial gravity during 60-day head-down bed rest-Insights from 4D flow cardiac MRI.Frontiers in physiology · 2022Article
- Hemodynamic Abnormalities in the Aorta of Turner Syndrome Girls.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensive-treated SHRs. Twenty-four adult male SHRs and Wistar-Kyoto rats (WKYs) were randomly divided into four groups and treated for 7 days as follows: WKY-CON (WKYs + saline), WKY-NIF (WKYs + nifedipine, 50 mg/kg/day), SHR-CON (SHRs + saline), and SHR-NIF (SHRs + nifedipine). Aortic computational fluid dynamics (CFD) models were simulated to obtain the haemodynamic parameters. We found that in the hypertensive (SHR-CON) and blood pressure-controlled (SHR-NIF) groups, the oscillatory shear index (OSI) and relative residence time (RRT), which are key haemodynamics indices, were markedly elevated. Furthermore, there was a correlation between both the elevated OSI and RRT with the vascular wall thickening in regions near the inner wall of the aortic arch. Our research demonstrates that haemodynamics remains disturbed even if the blood pressure is normalized. In addition, vascular remodelling may play an important role in maintaining elevated OSI and RRT values.
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