ArticleScience translational medicine2017
Central-acting therapeutics alleviate respiratory weakness caused by heart failure-induced ventilatory overdrive.
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Better Respiratory Function in Heart Failure Patients With Use of Central-Acting Therapeutics.CJC open · 2024Article
- A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence.Scientific reports · 2021Article
- Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway.Pharmacology research & perspectives · 2021Article
- We are the change we seek.American journal of physiology. Heart and circulatory physiology · 2021Article
- Hemodynamic assessment of diastolic function for experimental models.American journal of physiology. Heart and circulatory physiology · 2020Review
- Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy.Physiological reports · 2020Article
- Article
- Characterizing the influence of chronic hypobaric hypoxia on diaphragmatic myofilament contractile function and phosphorylation in high-altitude deer mice and low-altitude white-footed mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial HJournal of cachexia, sarcopenia and muscle · 2019Article
- Getting to the heart of myofibroblast differentiation: implications for scleraxis in ECM remodeling and therapeutic targeting.American journal of physiology. Heart and circulatory physiology · 2018Article
- Moderate and severe hypoxia elicit divergent effects on cardiovascular function and physiological rhythms.The Journal of physiology · 2018Article
- Commentary: Central-acting therapeutics alleviate respiratory weakness caused by heart failure-induced ventilatory overdrive.Frontiers in physiology · 2018Article
- Pathophysiological Mapping of Experimental Heart Failure: Left and Right Ventricular Remodeling in Transverse Aortic Constriction Is Temporally, Kinetically and Structurally Distinct.Frontiers in physiology · 2018Article
- Heart failure: HF-induced diaphragmatic atrophy and weakness.Nature reviews. Cardiology · 2017Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Diaphragmatic weakness is a feature of heart failure (HF) associated with dyspnea and exertional fatigue. Most studies have focused on advanced stages of HF, leaving the cause unresolved. The long-standing theory is that pulmonary edema imposes a mechanical stress, resulting in diaphragmatic remodeling, but stable HF patients rarely exhibit pulmonary edema. We investigated how diaphragmatic weakness develops in two mouse models of pressure overload-induced HF. As in HF patients, both models had increased eupneic respiratory pressures and ventilatory drive. Despite the absence of pulmonary edema, diaphragmatic strength progressively declined during pressure overload; this decline correlated with a reduction in diaphragm cross-sectional area and preceded evidence of muscle weakness. We uncovered a functional codependence between angiotensin II and β-adrenergic (β-ADR) signaling, which increased ventilatory drive. Chronic overdrive was associated with increased PERK (double-stranded RNA-activated protein kinase R-like ER kinase) expression and phosphorylation of EIF2α (eukaryotic translation initiation factor 2α), which inhibits protein synthesis. Inhibition of β-ADR signaling after application of pressure overload normalized diaphragm strength,
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Registered trials
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