Evidence map›Paper›PMID 28515324›Full record

ArticleThe Journal of biological chemistry2017

The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements.

Haoran Li, Martin Stümpfig, Caiguo Zhang, Xiuxiang An, JoAnne Stubbe, Roland Lill, Mingxia Huang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity.International journal of molecular sciences · 2024
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  6. Review
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  9. Review
  10. Radicals in Biology: Your Life Is in Their Hands.Journal of the American Chemical Society · 2021
    Article
  11. Article
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  13. Article
  14. Article
  15. mBio · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Haoran LiFrom the Departments of Chemistry and.
Martin StümpfigInstitut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, 35032 Marburg, Germany, and.
Caiguo Zhangthe Departments of Dermatology and.
Xiuxiang AnBiochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
JoAnne StubbeFrom the Departments of Chemistry and.
Roland LillInstitut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, 35032 Marburg, Germany, and lill@staff.uni-marburg.de.
Mingxia Huangthe Departments of Dermatology and mingxia.huang@ucdenver.edu.
University of Colorado Denver · USPhilipps University of Marburg · DEMassachusetts Institute of Technology · US

Funding

Ribonucleotide Reductase Regulation: Diferric Y* assembly/maintenance and Sml1R01GM081393 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI STUBBE, JOANNE · 2008 to 2016
$3.9M
In Vivo Regulation and Inhibition of Ribonucleotide ReductaseR01CA125574 · NCI · UNIVERSITY OF COLORADO DENVER · PI HUANG, MINGXIA · 2008 to 2012
$1.6M
NCI NIH HHS R01 CA125574NIGMS NIH HHS R01 GM081393
6 · The paper itself

Abstract

How each metalloprotein assembles the correct metal at the proper binding site presents challenges to the cell. The di-iron enzyme ribonucleotide reductase (RNR) uses a diferric-tyrosyl radical (Fe

Indexed as

Free RadicalsGlutaredoxinsIron-Sulfur ProteinsOxidoreductasesRibonucleotide ReductasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDre2 protein, S cerevisiaeFree RadicalsGlutaredoxinsGrx3 protein, S cerevisiaeGrx4 protein, S cerevisiaeIron-Sulfur ProteinsOxidoreductasesRibonucleotide ReductasesSaccharomyces cerevisiae ProteinsTah18 protein, S cerevisiaedeoxyribonucleotide biosynthesiselectron transferiron metabolismiron-sulfur clusteriron-sulfur proteinmetallocofactormetalloproteinribonucleotide reductase

Identifiers

PMID28515324
PMCPMC5500809
OpenAlexW2614543182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.