Evidence map›Paper›PMID 28515323›Full record

ArticleThe Journal of biological chemistry2017

β-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure.

Micah B Schott, Karuna Rasineni, Shaun G Weller, Ryan J Schulze, Arthur C Sletten, Carol A Casey, Mark A McNiven

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 73 citations in OpenAlex.

  1. Heterogeneity, dynamics and organelle interactions of lipid droplets.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Siah2 regulates lipid uptake in adipose tissue macrophages.The Journal of biological chemistry · 2026
    Article
  4. Article
  5. Article
  6. Lipid Droplet Dynamics in Alcoholic Steatohepatitis.The American journal of pathology · 2026
    Review
  7. Article
  8. ATP8B1 Deficiency Causes Phosphodiesterase 4-Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
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  10. Article
  11. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Micah B SchottDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905.
Karuna RasineniDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Shaun G WellerDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905.
Ryan J SchulzeDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905.
Arthur C SlettenDivision of Gastroenterology & Hepatology, Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905.
Carol A CaseyDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198; Nebraska Western Iowa Health Care System Research Service, Omaha, Nebraska 68105.
Mark A McNivenDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905. Electronic address: mmcniven.mark@mayo.edu.
Mayo Clinic · USUniversity of Nebraska Medical Center · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2M
DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver DiseaseR01AA020735 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASEY, CAROL A., MC NIVEN, MARK A. · 2011 to 2025
$8.1M
CYTOSKELETAL REGULATION OF VESICLE TRANSPORT IN LIVERR01DK044650 · NIDDK · MAYO CLINIC ROCHESTER · PI MC NIVEN, MARK A. · 1997 to 2020
$3.3M
NIAAA NIH HHS R01 AA020735NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK044650NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

In liver steatosis (

Indexed as

AcyltransferasesAdrenergic beta-AgonistsAnimalsCell Line, TumorCells, CulturedCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme ActivationFatty Liver, AlcoholicFemaleHepatocytesHumansLipaseLipid DropletsLipolysisMaleAcyltransferasesAdrenergic beta-AgonistsCyclic AMPCyclic AMP-Dependent Protein KinasesLipasePNPLA2 protein, ratReceptors, Adrenergic, betaSterol Esteraseadipose triglyceride lipase (ATGL)adrenergic receptoralcoholcyclic AMP (cAMP)fatty liverG protein-coupled receptor (GPCR)hepatocytelipid droplet

Identifiers

PMID28515323
PMCPMC5512075
OpenAlexW2616648530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.