ArticleThe Journal of biological chemistry2017
Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Impaired docking and recycling of synaptic vesicles in inherited lysosomal sphingolipidoses.Cell communication and signaling : CCS · 2025Article
- κ-Opioid Receptor Agonists as Robust Pain-Modulating Agents: Mechanisms and Therapeutic Potential in Pain Modulation.Journal of clinical medicine · 2025Review
- Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy.Neurobiology of disease · 2025Article
- Proenkephalin 119-159 in Heart Failure: From Pathophysiology to Clinical Implications.Journal of clinical medicine · 2025Review
- Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biasing GMolecular pharmacology · 2024Article
- Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs.The Journal of cell biology · 2023Article
- Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.Frontiers in cellular neuroscience · 2023Article
- SNAP25 differentially contributes to GFrontiers in cellular neuroscience · 2023Article
- Transcriptome Analyses Provide Insights into the Auditory Function inAnimals : an open access journal from MDPI · 2022Article
- Synaptic Integration of Subquantal Neurotransmission by Colocalized G Protein-Coupled Receptors in Presynaptic Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Subtype-dependent regulation of Gβγ signalling.Cellular signalling · 2021Review
- Regulating quantal size of neurotransmitter release through a GPCR voltage sensor.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.The Journal of biological chemistry · 2020Article
- Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.Science signaling · 2019Article
- The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.The Journal of biological chemistry · 2019Review
- Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner.Scientific reports · 2019Article
- Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive.Frontiers in physiology · 2019Article
- GPCR regulation of secretion.Pharmacology & therapeutics · 2018Review
- GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Zack ZurawskiDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600.
Brian PageDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612-7308.
Michael C ChickaHoward Hughes Medical Institute and Department of Neuroscience, University of Wisconsin, Madison, Wisconsin, 53705.
Rebecca L BrindleyDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6600.
Christopher A WellsDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600.
Anita M PreiningerDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600.
Karren HydeDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600.
James A GilbertDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600.
Osvaldo Cruz-RodriguezDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109.
Kevin P M CurrieDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6600.
Edwin R ChapmanHoward Hughes Medical Institute and Department of Neuroscience, University of Wisconsin, Madison, Wisconsin, 53705.
Simon AlfordDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612-7308.
Heidi E HammDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6600. Electronic address: heidi.hamm@vanderbilt.edu.
Vanderbilt University · USHoward Hughes Medical Institute · USUniversity of Illinois Chicago · USUniversity of Michigan · USVanderbilt University Medical Center · US
Funding
Synaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7MG PROTEIN STRUCTURE/FUNCTIONR01EY010291 · NEI · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 1994 to 2010
$3.9MSynaptic Plasticity and the Dynamic Interactions Between Calcium and PresynapticR01MH084874 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALFORD, SIMON T · 2010 to 2014
$1.9MG-protein regulation of exocytotic transmitter releaseR01NS052446 · NINDS · VANDERBILT UNIVERSITY · PI CURRIE, KEVIN P · 2006 to 2010
$1.7MGPCR Regulation of insulin secretion by modulation of the release machineryR01DK109204 · NIDDK · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 2016 to 2019
$1.4MOptimization of modulators of Gbg-SNARE interactionR01MH101679 · NIMH · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E, STAUFFER, SHAUN R · 2014 to 2016
$1.2MNEI NIH HHS R01 EY010291NIDDK NIH HHS R01 DK109204NIMH NIH HHS R01 MH061876NIMH NIH HHS R01 MH084874NIMH NIH HHS R01 MH101679NINDS NIH HHS R01 NS052446
Abstract
G
Indexed as
Lipid BilayersModels, MolecularAnimalsBinding, CompetitiveCalcium SignalingCattleCell LineGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsHumansLiposomesMembrane FusionMutationNerve Tissue ProteinsPeptide FragmentsProtein ConformationGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsLipid BilayersLiposomesNerve Tissue ProteinsPeptide FragmentsRecombinant Fusion ProteinsRecombinant ProteinsSnap25 protein, ratStx1a protein, ratSynaptosomal-Associated Protein 25Synaptotagmin ISyntaxin 1Syt1 protein, ratexocytosisG proteinG protein-coupled receptor (GPCR)neurotransmitter releaseSNARE proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.