ArticleJournal of virology2017
Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.
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Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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0cells of the map it votes in
38citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
38 citing papers in PubMed, 50 citations in OpenAlex.
- Identification of fidelity-determined residues of Porcine reproductive and respiratory syndrome virus through structural alignment.Virulence · 2026Article
- Single amino acid substitution in RdRp reduces viral recombination frequency of NADC30-like porcine reproductive and respiratory syndrome virus type 2.PLoS pathogens · 2026Article
- Live-attenuated foot-and-mouth disease virus vaccine engineered by codon deoptimization induces a strong protective immune response in cattle.NPJ vaccines · 2026Article
- Foot-and-mouth disease: genomic and proteomic structure, antigenic sites, serotype relationships, immune evasion, recent vaccine development strategies, and future perspectives.Veterinary research · 2025Review
- Review
- DNA Polymerases for Whole Genome Amplification: Considerations and Future Directions.International journal of molecular sciences · 2023Review
- Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains.Viruses · 2023Article
- The Foot-and-Mouth Disease Virus Lb Protease Cleaves Intracellular Transcription Factors STAT1 and STAT2 to Antagonize IFN-β-Induced Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- The Second Human Pegivirus, a Non-Pathogenic RNA Virus with Low Prevalence and Minimal Genetic Diversity.Viruses · 2022Review
- Structural Analysis of Monomeric RNA-Dependent Polymerases Revisited.Journal of molecular evolution · 2022Article
- Review
- Identification of Single Amino Acid Changes in the Rift Valley Fever Virus Polymerase Core Domain Contributing to Virus AttenuationFrontiers in cellular and infection microbiology · 2022Article
- Amber codon is genetically unstable in generation of premature termination codon (PTC)-harbouring Foot-and-mouth disease virus (FMDV) via genetic code expansion.RNA biology · 2021Article
- A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase.Nucleic acids research · 2021Article
- Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures.Viruses · 2021Article
- Polymerase Fidelity Contributes to Foot-and-Mouth Disease Virus Pathogenicity and TransmissibilityJournal of virology · 2020Article
- Residues within the Foot-and-Mouth Disease Virus 3DJournal of virology · 2020Article
- A Temperature-Dependent Translation Defect Caused by Internal Ribosome Entry Site Mutation Attenuates Foot-and-Mouth Disease Virus: Implications for Rational Vaccine Design.Journal of virology · 2020Article
- A Low Fidelity Virus Shows Increased Recombination during the Removal of an Alphavirus Reporter Gene.Viruses · 2020Article
- Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses.Vaccines · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Devendra K RaiPlum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA.
Fayna Diaz-San SegundoPlum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA.
Grace CampagnolaDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.
Anna KeithDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.
Elizabeth A SchaferPlum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA.
Anna KlocPlum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA.
Teresa de Los SantosPlum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA.
Olve PeersenDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.
Elizabeth RiederPlum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA Elizabeth.Rieder@ars.usda.gov.
Plum Island Animal Disease Center · USColorado State University · USUniversity of Connecticut · US
Funding
Assembly of Picornaviral Replication ComplexesR01AI059130 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI PEERSEN, OLVE BREIEN · 2004 to 2021
$4.6MAssembly of Picornaviral Replication ComplexesR37AI059130 · NIAID · COLORADO STATE UNIVERSITY · PI Olve Breien Peersen · 2023 to 2026
$1.5MEngineering Viral Polymerase Fidelity to Improve Live-Attenuated VaccinesR21AI124123 · NIAID · COLORADO STATE UNIVERSITY · PI OSORIO, JORGE E, PEERSEN, OLVE BREIEN · 2016 to 2017
$431kNIAID NIH HHS R21 AI124123NIAID NIH HHS R37 AI059130
Abstract
Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D
Indexed as
Protein EngineeringAmino Acid SubstitutionAnimalsAntigens, ViralAntiviral AgentsCells, CulturedCricetinaeDisease Models, AnimalDNA Mutational AnalysisDrug Resistance, ViralFluorouracilFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusMiceMutagenesis, Site-DirectedPoint MutationAntigens, ViralAntiviral AgentsFluorouracilRibavirinTryptophanViral Nonstructural Proteinsvirus-infection-associated antigen, Foot-and-mouth disease virus3Dpol3D polymerasefoot-and-mouth disease viruspicornavirusRNA-dependent RNA polymerase fidelity
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.