Evidence map›Paper›PMID 28515221›Full record

ArticleBioscience reports2017

Regulation of cerebral arterial BKCa channels by angiotensin II signaling in adult offspring exposed to prenatal high sucrose diets.

Xiuxia Gu, Axin He, Xiaorong Fan, Ruixiu Shi, Xueqin Feng, Le Bo, Lin Jiang, Na Li, Jue Wu, Yuxian Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xiuxia GuInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Axin HeInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Xiaorong FanInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Ruixiu ShiInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Xueqin FengInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Le BoInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Lin JiangInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Na LiInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Jue WuInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Yuxian YangInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Qinqin GaoInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China jennyqgao@126.com xuzhice@suda.edu.cn.
Zhice XuInstitute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China jennyqgao@126.com xuzhice@suda.edu.cn.
First Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal insults have been shown to affect vascular functions, leading to increased risks of cardiovascular diseases in offspring. The present study determined whether high sucrose (HS) intake in pregnancy affected central vascular functions in middle cerebral artery (MCA) of offspring. Sprague-Dawley rats were fed a standard food and tap water with normal or high (20%) sucrose content during pregnancy. Offspring were maintained with normal diets and tap water. Central vascular functions and related ion channels were assessed in male offspring at 5 months old. Compared with the control, angiotensin II (AII)-induced vasoconstrictions were significantly higher in the MCA of the offspring exposed to prenatal HS. In the MCA, large conductance Ca

Indexed as

Analysis of VarianceAngiotensin IIAnimalsBrainCalciumDietDietary SucroseFemaleGlucoseLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMaleMicrovesselsMiddle Cerebral ArteryPatch-Clamp TechniquesPotassiumPregnancyAngiotensin IICalciumDietary SucroseGlucoseKcnma1 protein, ratLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPotassiumReceptors, AngiotensinAdult offspringAngiotensin IIBKCa channelsMiddle cerebral arteryPrenatal high sucrose diets

Identifiers

PMID28515221
PMCPMC5479054
OpenAlexW2615146259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.