ArticleAmerican journal of physiology. Renal physiology2017
Cross-sex transplantation alters gene expression and enhances inflammatory response in the transplanted kidneys.
Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation.The Cochrane database of systematic reviews · 2024Pooled it
- Macula densa nitric oxide synthase 1β restoration by kidney alkalization enhances renal graft outcomes.American journal of physiology. Renal physiology · 2025Article
- Sex Differences in the Initiation and Progression of Necroptosis Following Kidney Ischemia-Reperfusion Injury.Biomedicines · 2025Article
- Enhancing Liver Transplant Outcomes through Liver Precooling to Mitigate Inflammatory Response and Protect Mitochondrial Function.Biomedicines · 2024Article
- Hemodynamic Renal Reserve Response in Conscious Normotensive and Hypertensive Mice.Kidney & blood pressure research · 2024Article
- Macula Densa Nitric Oxide Synthase 1 Controls Renin Release and Renin-Dependent Blood Pressure Changes.Discovery medicine · 2023Article
- Article
- A mouse model of renal ischemia-reperfusion injury solely induced by cold ischemia.American journal of physiology. Renal physiology · 2019Article
- Graft function assessment in mouse models of single- and dual-kidney transplantation.American journal of physiology. Renal physiology · 2018Article
- Effects of different storage solutions on renal ischemia tolerance after kidney transplantation in mice.American journal of physiology. Renal physiology · 2018Article
- Role of Kidneys in Sex Differences in Angiotensin II-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole.Physiological genomics · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Kidney transplantation (KTX) is a life-saving procedure for patients with end-stage renal disease. Expression levels of many genes in the kidney vary between males and females, which may play an essential role in the sex differences in graft function. However, whether these differences are affected after cross-sex-KTX is unknown. In the present study, we assessed postoperative changes in genotype, function, and inflammatory responses of the grafts in same-sex- and cross-sex-KTX. Single kidney transplants were performed between same and different sex C57BL/6 mice paired into four combination groups: female donor/female recipient (F/F); male donor/male recipient (M/M); female donor/male recipient (F/M); and male donor/female recipient (M/F). The remnant native kidney was removed 4 days posttransplant. Expression levels of genes related to the contractility of the afferent arteriole and tubular sodium reabsorption were assessed. Same-sex-KTX did not significantly alter the magnitude or sex difference pattern of gene expression in male or female grafts. Cross-sex-KTX showed an attenuated sex difference in gene expressions. The measurements of endothelin 1, endothelin ET
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