Evidence map›Paper›PMID 28515150›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.

John Evankovich, Travis Lear, Alison Mckelvey, Sarah Dunn, James Londino, Yuan Liu, Bill B Chen, Rama K Mallampalli

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Geranylgeranylated SCFCell reports · 2024
    Article
  3. Geranylgeranylated-SCFbioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Observational
  8. Article
  9. The role of RAGE in host pathology and crosstalk between RAGE and TLR4 in innate immune signal transduction pathways.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Review
  10. Article
  11. Article
  12. Kiss of Death: Ring Finger 216 Regulates Toll-like Receptor 8 Stability through Ubiquitination.American journal of respiratory cell and molecular biology · 2020
    Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

John EvankovichAcute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Travis LearUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; and.
Alison MckelveyUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; and.
Sarah DunnUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; and.
James LondinoAcute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yuan LiuAcute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bill B ChenAcute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rama K MallampalliAcute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; mallampalirk@upmc.edu.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, PRABIR · 2014 to 2023
$21.3M
Translational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3M
TNF-alpha Control of a Surfactant Enzyme in Lung InjuryR01HL081784 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2006 to 2024
$5.4M
F box-Induced Acute Lung Injury and ParkinR01HL096376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2025
$5.1M
Sepsis-Associated Immune Suppression and F-box ProteinsR01HL097376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2009 to 2025
$5.1M
A New Genus of Ubiquitin-Based Anti-inflammatories for COPDUH3HL123502 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2016 to 2018
$4.6M
Stabilizing mitochondria in sepsisR01HL098174 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2021
$3.6M
Regulation of Innate Immunity by F-Box ProteinsR01HL116472 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI · 2013 to 2017
$1.9M
HECT-domain E3 Ligase and Acute Lung InjuryR01HL132862 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI · 2016 to 2017
$976k
Degradation of The Receptor for Advanced Glycation End Products (RAGE) - A Novel Mechanism in Lung Epithelial Cell InjuryF32HL137258 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EVANKOVICH, JOHN W · 2017 to 2018
$113k
NHLBI NIH HHS F32 HL137258NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL081784NHLBI NIH HHS R01 HL096376NHLBI NIH HHS R01 HL097376NHLBI NIH HHS R01 HL098174NHLBI NIH HHS R01 HL116472NHLBI NIH HHS R01 HL132862NHLBI NIH HHS T32 HL007563NHLBI NIH HHS UH3 HL123502
6 · The paper itself

Abstract

The receptor for advanced glycation end products (RAGE) is a highly expressed cell membrane receptor serving to anchor lung epithelia to matrix components, and it also amplifies inflammatory signaling during acute lung injury. However, mechanisms that regulate its protein concentrations in cells remain largely unknown. Here we show that RAGE exhibits an extended life span in lung epithelia (

Indexed as

ProteolysisUbiquitinationAnimalsAntigens, NeoplasmCell LineCpG IslandsDNAF-Box ProteinsGene ExpressionGene Expression RegulationGene Knockdown TechniquesHumansMiceMitogen-Activated Protein KinasesMutagenesis, Site-DirectedOligodeoxyribonucleotidesAger protein, mouseAntigens, NeoplasmDNAF-Box ProteinsFBXO10 protein, humanMitogen-Activated Protein KinasesMOK protein, humanODN2006OligodeoxyribonucleotidesProtein Kinase CProtein Kinase C zetaReceptor for Advanced Glycation End Productsacute lung injuryF-box proteinsubiquitin

Identifiers

PMID28515150
PMCPMC5572686
OpenAlexW2615877256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.