Evidence map›Paper›PMID 28515147›Full record

ArticleCancer research2017

Increased T-cell Infiltration Elicited by

Carolyn J Loveridge, Ernest J Mui, Rachana Patel, Ee Hong Tan, Imran Ahmad, Michelle Welsh, Julie Galbraith, Ann Hedley, Colin Nixon, Karen Blyth and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. MAPK ERK5 is a novel regulator of MHC-I in cancer cells.Cell communication and signaling : CCS · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Chemokine signaling in cancer-stroma communications.Journal of cell communication and signaling · 2021
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Elevation of pulmonary CD163Journal of thoracic disease · 2019
    Article
  12. Therapeutic targeting of trained immunity.Nature reviews. Drug discovery · 2019
    Review
  13. Impact of ERK5 on the Hallmarks of Cancer.International journal of molecular sciences · 2019
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Carolyn J LoveridgeInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, United Kingdom.
Ernest J MuiCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Rachana PatelCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Ee Hong TanCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Imran AhmadInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, United Kingdom.
Michelle WelshCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Julie GalbraithInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, United Kingdom.
Ann HedleyCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Colin NixonCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Karen BlythCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Owen SansomCRUK Beatson Institute, Bearsden, Glasgow, United Kingdom.
Hing Y LeungInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, United Kingdom. h.leung@beatson.gla.ac.uk.
Cancer Research UK Scotland Institute · GBUniversity of Glasgow · GB

Funding

Cancer Research UK 21139Cancer Research UK 22904Cancer Research UK A15151Cancer Research UK A17196Prostate Cancer UK PG10-10
6 · The paper itself

Abstract

Prostate cancer does not appear to respond to immune checkpoint therapies where T-cell infiltration may be a key limiting factor. Here, we report evidence that ablating the growth regulatory kinase

Indexed as

AnimalsCD4-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalHumansImage Processing, Computer-AssistedImmunohistochemistryIn Situ HybridizationLaser Capture MicrodissectionLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 7Prostatic NeoplasmsMitogen-Activated Protein Kinase 7PTEN Phosphohydrolase

Identifiers

PMID28515147
PMCPMC5474317
OpenAlexW2616350383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.