ArticleDiabetes2017
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.
Open access · hybridAbstract readEvaluation Study
In one paragraph
Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Emerging Theranostic Radiometals (Pharmaceuticals (Basel, Switzerland) · 2026Review
- First positronium lifetime imaging usingScientific reports · 2026Article
- HER2 expression in different cell lines at different inoculation sites assessed by [Pathology oncology research : POR · 2025Article
- Development of an ostrich-derived single-chain variable fragment (scFv) against PTPRN extracellular domain.Scientific reports · 2024Article
- New Insights and Potential Therapeutic Interventions in Metabolic Diseases.International journal of molecular sciences · 2023Review
- GLP-1R Signaling and Functional Molecules in Incretin Therapy.Molecules (Basel, Switzerland) · 2023Review
- Impact of anFrontiers in endocrinology · 2023Article
- Imaging zinc trafficking in vivo by positron emission tomography with zinc-62.Metallomics : integrated biometal science · 2022Article
- Non-invasive radionuclide imaging of trace metal trafficking in health and disease: "PET metallomics".RSC chemical biology · 2022Review
- Excitation function ofNuclear physics. A · 2022Article
- Myocardial Viability Imaging using Manganese-Enhanced MRI in the First Hours after Myocardial Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Non-invasive Beta-cell Imaging: Visualization, Quantification, and Beyond.Frontiers in endocrinology · 2021Review
- ImmunoPET: Concept, Design, and Applications.Chemical reviews · 2020Review
- Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.Dalton transactions (Cambridge, England : 2003) · 2020Article
- PET/MRI enables simultaneousTheranostics · 2020Article
- Manganese in PET imaging: Opportunities and challenges.Journal of labelled compounds & radiopharmaceuticals · 2019Review
- Molecular imaging of β-cells: diabetes and beyond.Advanced drug delivery reviews · 2019Review
- Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.Scientific reports · 2018Article
- Insights into Trace Metal Metabolism in Health and Disease from PET: "PET Metallomics".Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Review
- Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography.Molecular imaging and biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Reinier HernandezDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI.
Stephen A GravesDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI.
Trillian GreggDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, WI.
Halena R VanDeusenDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, WI.
Rachel J FenskeDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, WI.
Haley N WienkesDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, WI.
Christopher G EnglandDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI.
Hector F ValdovinosDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI.
Justin J JefferyCarbone Cancer Center, University of Wisconsin-Madison, Madison, WI.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI.
Gregory W SeverinCenter for Nuclear Technologies, Technical University of Denmark, Roskilde, Denmark.
Robert J NicklesDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI.
Michelle E KimpleDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, WI.
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, WI merrins@wisc.edu wcai@uwhealth.org.ORCID 0000-0003-1599-9227
Weibo CaiDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI merrins@wisc.edu wcai@uwhealth.org.ORCID 0000-0003-4641-0833
University of Wisconsin–Madison · USMichigan State University · US
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6MBIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5MU.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1MPREDOCTORAL TRAINING IN MOLECULAR BIOPHYSICST32GM008293 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI JACKSON, MEYER B. · 1989 to 2016
$4.6MMetabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta CellsR01DK113103 · NIDDK · YALE UNIVERSITY · PI Matthew J. Merrins · 2017 to 2026
$3.3MMolecular Mechanisms of Dysfunctional Prostaglandin Signaling in the Beta-CellR01DK102598 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, MICHELLE E · 2014 to 2018
$1.7MMembranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7MNovel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903kApplication for Administrative Supplement to Existing Award AG050135 to Develop Research on Alzheimer's DiseaseR21AG050135 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM, MERRINS, MATTHEW J. · 2016 to 2017
$568kCyclin-Dependant Kinase 2 (CDK2) Function in Pancreatic Beta-CellsK01DK101683 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MERRINS, MATTHEW J. · 2014 to 2016
$426kNCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS T32 CA009206NIA NIH HHS R21 AG050135NIBIB NIH HHS R01 EB021336NIDDK NIH HHS K01 DK101683NIDDK NIH HHS R01 DK102598NIDDK NIH HHS R01 DK113103NIGMS NIH HHS T32 GM008293NIGMS NIH HHS T32 GM008349
Abstract
The noninvasive measurement of functional β-cell mass would be clinically valuable for monitoring the progression of type 1 and type 2 diabetes as well as the viability of transplanted insulin-producing cells. Although previous work using MRI has shown promise for functional β-cell mass determination through voltage-dependent Ca
Indexed as
AnimalsCalcium ChannelsCase-Control StudiesCell SizeDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Disease ProgressionHumansInsulin-Secreting CellsManganese CompoundsMicePancreasPositron-Emission TomographyRadiopharmaceuticalsStreptozocinCalcium ChannelsManganese CompoundsRadiopharmaceuticalsStreptozocin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.