Evidence map›Paper›PMID 28515060›Full record

ArticleBone & joint research2017

Barriers and facilitators experienced in collaborative prospective research in orthopaedic oncology: A qualitative study.

J S Rendon, M Swinton, N Bernthal, M Boffano, T Damron, N Evaniew, P Ferguson, M Galli Serra, W Hettwer, P McKay and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone & joint research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Bridging the gap: understanding and enhancing the collaborative relationship between spine clinicians and researchers of the International Society for the Study of the Lumbar Spine (ISSLS).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

J S RendonMcMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON, Canada.
M SwintonMcMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON, Canada.
N BernthalDepartment of Orthopaedic Surgery, University of California Los Angeles, 1250 16 Street, Suite 3142, Santa Monica, Los Angeles, CA, 90404, USA.
M BoffanoDepartment of Orthopaedics, AO Città della Salute e della Scienza di Torino, Via Zuretti 29, Torino, 10126 Italy.
T DamronState University of New York (SUNY) Upstate Medical University, 6620 Fly Road, Suite 100, East Syracuse, NY, 13057, USA.
N EvaniewMcMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON, Canada.
P FergusonDivision Chair, Division of Orthopaedic Surgery, University of Toronto, 600 University Avenue, Suite 476G, Toronto, ON, Canada.
M Galli SerraUniversidad Austral, Av. Juan Domingo Péron 1500, 4to. Piso, Derqui B1629ODT Pilar, Buenos Aires, Argentina.
W HettwerDepartment of Orthopaedic Surgery, University of Copenhagen, Copenhagen, 2100, Denmark.
P McKayMcMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON, Canada.
B MillerDepartment of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, 01015 JPP, Iowa City, USA.
L NystromDepartment of Orthopaedic Surgery and Rehabilitation, Loyola University Chicago, 2160 South First Avenue, Maywood, IL, 60153, USA.
W ParizziaUniversidad Austral, Av. Juan Domingo Péron 1500, 4to. Piso, Derqui B1629ODT Pilar, Buenos Aires, Argentina.
P SchneiderMcMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON, Canada.
A SpiguelDepartment of Orthopaedics and Rehabilitation, University of Florida, 3450 Hull Road, Gainesville, FL, 32607, USA.
R VélezDepartment of Orthopaedic Surgery and Traumatology, Hospital Vall d'Hebron, Pg. Vall d'Hebron 119-129, 2a planta, Barcelona, Spain.
K WeissDepartment of Orthopaedic Surgery, University of Pittsburgh, 5200 Centre Avenue, Shadyside Medical Building, Suite 415, Pittsburgh, PA, USA.
J P ZumárragaDepartment of Orthopaedics and Traumatology, Universidade de São Paulo, Universidade de São Paulo, Rua Dr. Ovídio Pires de Campos, 333, Cerqueira Cesar, São Paulo, SP, Brazil.
M GhertDepartment of Surgery, McMaster University, 711 Concession Street, Surgical Offices B3 169A | Hamilton, ON, Canada ghert@hhsc.ca.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Exploring Sarcoma Metastatic PotentialK08CA177927 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISS, KURT RICHARD · 2013 to 2017
$827k
Modifying and Delivering Antimicrobials to Prevent Orthopaedic Implant InfectionsK08AR069112 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERNTHAL, NICHOLAS M. · 2016 to 2019
$704k
NCI NIH HHS K08 CA177927NIAMS NIH HHS K08 AR069112
6 · The paper itself

Abstract

objectivesAs tumours of bone and soft tissue are rare, multicentre prospective collaboration is essential for meaningful research and evidence-based advances in patient care. The aim of this study was to identify barriers and facilitators encountered in large-scale collaborative research by orthopaedic oncological surgeons involved or interested in prospective multicentre collaboration.

methodsAll surgeons who were involved, or had expressed an interest, in the ongoing Prophylactic Antibiotic Regimens in Tumour Surgery (PARITY) trial were invited to participate in a focus group to discuss their experiences with collaborative research in this area. The discussion was digitally recorded, transcribed and anonymised. The transcript was analysed qualitatively, using an analytic approach which aims to organise the data in the language of the participants with little theoretical interpretation.

resultsThe 13 surgeons who participated in the discussion represented orthopaedic oncology practices from seven countries (Argentina, Brazil, Italy, Spain, Denmark, United States and Canada). Four categories and associated themes emerged from the discussion: the need for collaboration in the field of orthopaedic oncology due to the rarity of the tumours and the need for high level evidence to guide treatment; motivational factors for participating in collaborative research including establishing proof of principle, learning opportunity, answering a relevant research question and being part of a collaborative research community; barriers to participation including funding, personal barriers, institutional barriers, trial barriers, and administrative barriers and facilitators for participation including institutional facilitators, leadership, authorship, trial set-up, and the support of centralised study coordination.

conclusionsOrthopaedic surgeons involved in an ongoing international randomised controlled trial (RCT) were motivated by many factors to participate. There were a number of barriers to and facilitators for their participation. There was a collective sense of fatigue experienced in overcoming these barriers, which was mirrored by a strong collective sense of the importance of, and need for, collaborative research in this field. The experiences were described as essential educational first steps to advance collaborative studies in this area. Knowledge gained from this study will inform the development of future large-scale collaborative research projects in orthopaedic oncology.

Indexed as

Collaborative researchFocus groupOrthopaedic oncology

Identifiers

PMID28515060
PMCPMC5457637

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.