ArticleBone & joint research2017
Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement.
Article in Bone & joint research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 76 citations in OpenAlex.
- Antimicrobial-loaded PMMA bone cement: time for good practice recommendations.The Journal of antimicrobial chemotherapy · 2026Article
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- Enhancement of tobramycin and amikacin activities by co-encapsulation in liposomal-thymoquinone formulation: antibacterial, antibiofilm, and cytocompatibility study.Therapeutic delivery · 2026Article
- Gentamicin fails to eradicateJournal of bone and joint infection · 2026Article
- A review of the Masquelet technique in the treatment of lower limb critical-size bone defects.Annals of the Royal College of Surgeons of England · 2025Review
- Comparative efficacy of tetracyclines against isolates ofIJTLD open · 2025Article
- Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment.Drug delivery · 2024Article
- Amoxicillin/clavulanate in combination with rifampicin/clarithromycin is bactericidal against Mycobacterium ulcerans.PLoS neglected tropical diseases · 2024Article
- Vacuum assisted closure and local drug delivery systems in spinal infections: A review of current evidence.North American Spine Society journal · 2023Article
- A novel coli myophage and antibiotics synergistically inhibit the growth of the uropathogenicMicrobiology spectrum · 2023Article
- Ribosome-binding antibiotics increase bacterial longevity and growth efficiency.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Highly Adhesive Antimicrobial Coatings for External Fixation Devices.Gels (Basel, Switzerland) · 2023Article
- Local Antibiotic Delivery Options in Prosthetic Joint Infection.Antibiotics (Basel, Switzerland) · 2023Review
- Bacterial growth and ceftriaxone activity in individual ascitic fluids in anFrontiers in pharmacology · 2023Article
- Development and Characterization of a Subcutaneous Implant-Related Infection Model in Mice to Test Novel Antimicrobial Treatment Strategies.Biomedicines · 2022Article
- Evidence for Local Antibiotics in the Prevention of Infection in Orthopaedic Trauma.Journal of clinical medicine · 2022Review
- Development of Thermoresponsive-Gel-Matrix-Embedded Amoxicillin Trihydrate-Loaded Bovine Serum Albumin Nanoparticles for Local Intranasal Therapy.Gels (Basel, Switzerland) · 2022Article
- Wound fluid ceftriaxone concentrations after local application with calcium sulphate as carrier material in the treatment of orthopaedic device-associated hip infections.Bone & joint research · 2022Article
- [Salvage procedure for chronic periprosthetic infection : Use of a rifampicin-loaded polymethyl methacrylate spacer].Unfallchirurgie (Heidelberg, Germany) · 2022Article
- Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections. Despite the fact that long-term therapy is a stated goal of novel local delivery carriers, data describing thermal stability over a long period are scarce, and studies that avoid interference from specific carrier materials are absent from the orthopaedic literature.
methodsIn this study, a total of 38 frequently used antibiotic agents were maintained at 37°C in saline solution, and degradation and antibacterial activity assessed over six weeks. The impact of an initial supplementary heat exposure mimicking exothermically curing bone cement was also tested as this material is commonly used as a local delivery vehicle. Antibiotic degradation was assessed by liquid chromatography coupled to mass spectrometry, or by immunoassays, as appropriate. Antibacterial activity over time was determined by the Kirby-Bauer disk diffusion assay.
resultsThe heat exposure mimicking curing bone cement had minimal effect on stability for most antibiotics, except for gentamicin which experienced approximately 25% degradation as measured by immunoassay. Beta-lactam antibiotics were found to degrade quite rapidly at 37°C regardless of whether there was an initial heat exposure. Excellent long-term stability was observed for aminoglycosides, glycopeptides, tetracyclines and quinolones under both conditions.
conclusionsThis study provides a valuable dataset for orthopaedic surgeons considering local application of antibiotics, and for material scientists looking to develop next-generation controlled or extended-release antibiotic carriers.
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