ReviewTrends in neurosciences2017
Aberrant Network Activity in Schizophrenia.
Review in Trends in neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Axo-axonic cells in neuropsychiatric disorders: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Multimodal evidence for a mechanistic model of working memory deficits in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia.Schizophrenia bulletin · 2026Article
- Effects of NMDA receptor antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Computational modelling of schizophrenia-associated alterations of ion-channel-encoding gene expression predicts a decrease in delta power.bioRxiv : the preprint server for biology · 2025Article
- Novel electroencephalographic biomarkers for the prediction of responders to an experimental glutamatergic agent in patients with schizophrenia.Translational psychiatry · 2025Article
- Aberrant Functional Connectivity and Brain Network Organization in High-Schizotypy Individuals: An Electroencephalography Study.Schizophrenia bulletin · 2025Article
- Seeing things in psychosis: Reduced theta power in early neural responses to ambiguous visual stimuli predicts perceptual distortions.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Generalized Slowing of Resting-State Neural Oscillations in People With Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The Instantaneous Effect and Its Mechanism of Transcranial Direct Current Stimulation on Working Memory Based on Delta and Gamma Band Electroencephalography Characteristics.Brain sciences · 2025Article
- Neural Mechanism of 5-HT4R-Mediated Memory Enhancement in Hippocampal-Prefrontal Circuits in a Mouse Model of Schizophrenia.International journal of molecular sciences · 2025Article
- Between neurons and networks: investigating mesoscale brain connectivity in neurological and psychiatric disorders.Frontiers in neuroscience · 2024Review
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Dopamine D4 Receptor Agonist Drastically Increases Delta Activity in the Thalamic Nucleus Reuniens: Potential Role in Communication between Prefrontal Cortex and Hippocampus.International journal of molecular sciences · 2023Article
- Assessment of electroencephalography modification by antipsychotic drugs in patients with schizophrenia spectrum disorders using frontier orbital theory: A preliminary study.Neuropsychopharmacology reports · 2023Article
- Neuropsychiatric consequences of COVID-19 related olfactory dysfunction: could non-olfactory cortical-bound inputs from damaged olfactory bulb also contribute to cognitive impairment?Frontiers in neuroscience · 2023Article
- Abnormal resting-state functional connectivity underlies cognitive and clinical symptoms in patients with schizophrenia.Frontiers in human neuroscience · 2023Article
- Development of network oscillations through adolescence in male and female rats.Frontiers in cellular neuroscience · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology. Changes in synaptic excitation and inhibition in schizophrenia disrupt delta rhythm-mediated cortico-cortical communication, while enhancing thalamocortical communication in this frequency band. The contrasting relationships between delta and higher frequencies in thalamus and cortex generate frequency mismatches in inter-regional connectivity, leading to a disruption in temporal communication between higher-order brain regions associated with mental time travel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.