ArticleDrug and alcohol dependence2017
The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Parental substance use history density and its influence on reward anticipation brain activation in late childhood and early adolescence.Developmental cognitive neuroscience · 2025Article
- Internal assets in low-income urban adolescents from 12 to 17 years: Gender variation.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Article
- Prenatal cocaine exposure and self-reported behavioral adjustments from ages 12 to 21: environmental pathways.Psychological medicine · 2024Article
- Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21.Drug and alcohol dependence · 2023Article
- Co-occurrence of Psychopathology Problems in At-Risk Adolescents.Journal of psychopathology and behavioral assessment · 2022Article
- Preschool blood lead levels, language competency, and substance use in adolescence.Environmental research · 2022Article
- Externalizing Risk Pathways for Adolescent Substance Use and Its Developmental Onset: A Canadian Birth Cohort Study: Trajectoires de comportements extériorisés et le risque pour l'initiation et l'usage de substances des adolescents : Une étude de cohorte de naissance canadienne.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Proceedings of the 2018 annual meeting of the Fetal Alcohol Spectrum Disorders study group.Alcohol (Fayetteville, N.Y.) · 2019Article
- Prenatal cocaine exposure: Direct and indirect associations with 21-year-old offspring substance use and behavior problems.Drug and alcohol dependence · 2019Article
- Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse.Neurobiology of stress · 2018Review
- Individual assets and problem behaviors in at-risk adolescents: A longitudinal cross-lagged analysis.Journal of adolescence · 2018Article
- Does prenatal cocaine exposure predict adolescent substance use?Neurotoxicology and teratologyArticle
- Prenatal cocaine exposure, early cannabis use, and risky sexual behavior at age 25.Neurotoxicology and teratologyArticle
- Prenatal drug exposure and executive function in early adolescence.Neurotoxicology and teratologyArticle
- Pathways from prenatal cocaine exposure to adult substance use and behavior.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Prenatal cocaine exposure (PCE) may increase adolescent substance use through alterations of neurotransmitter systems affecting fetal brain development. The relationship between PCE and substance use at 15 and 17 years was examined. Subjects (365: 186 PCE; 179 non-cocaine exposed (NCE)) supplied biologic and self-report data using the Youth Risk Behavior Surveillance System (YRBSS) and Computerized Diagnostic Interview Schedule for Children (C-DISC 4) at ages 15 and 17. The relationship between PCE and substance use was assessed using General Estimating Equation (GEE) analyses controlling for confounding factors including violence exposure and preschool lead level. Teens with PCE vs. NCE teens were 2 times more likely to use tobacco (OR=2.1; 95% CI 1.21-3.63; p<.001) and marijuana (OR=1.85; CI 1.18-2.91; p<.001) and have a substance use disorder at age 17 (OR=2.51; CI 1.00-6.28; p<.05). Evaluation of PCE status by gender revealed an association between PCE and marijuana use that was more pronounced for boys than girls at 17 years. Violence exposure was also a significant predictor of alcohol (p<.001), tobacco (p<.05), and marijuana (p<.0006) use and substance abuse/dependence (p<.01). Externalizing behavior at age 12 fully mediated the effects of PCE on substance use disorder at age 17 and partially mediated effects of PCE on tobacco use, but did not mediate effects on marijuana use. The percentage of substance use reported increased between 15 and 17 years, with no differences between the PCE and NCE groups. Data suggest specialized drug use prevention measures for children with PCE may benefit this high risk group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.