Evidence map›Paper›PMID 28514655›Full record

ArticleCell reports2017

Inhibitory Control of Feature Selectivity in an Object Motion Sensitive Circuit of the Retina.

Tahnbee Kim, Daniel Kerschensteiner

Abstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
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  10. Article
  11. Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse.Investigative ophthalmology & visual science · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tahnbee KimDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA; Graduate Program in Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Daniel KerschensteinerDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University School of Medicine, Saint Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: kerschensteinerd@wustl.edu.

Funding

SYNAPTIC ORGANIZATION AND VISUAL PROCESSING IN INTERNEURON CIRCUITS OF THE RETINAR01EY026978 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2016 to 2026
$3.8M
Synapse rescue and neuroprotection in the retinaR01EY027411 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2017 to 2026
$3.4M
Neuronal plasticity in retinal circuit development and diseaseR01EY023341 · NEI · WASHINGTON UNIVERSITY · PI KERSCHENSTEINER, DANIEL · 2014 to 2022
$2.8M
NEI NIH HHS R01 EY023341NEI NIH HHS R01 EY026978NEI NIH HHS R01 EY027411
6 · The paper itself

Abstract

Object motion sensitive (OMS) W3-retinal ganglion cells (W3-RGCs) in mice respond to local movements in a visual scene but remain silent during self-generated global image motion. The excitatory inputs that drive responses of W3-RGCs to local motion were recently characterized, but which inhibitory neurons suppress W3-RGCs' responses to global motion, how these neurons encode motion information, and how their connections are organized along the excitatory circuit axis remains unknown. Here, we find that a genetically identified amacrine cell (AC) type, TH2-AC, exhibits fast responses to global motion and slow responses to local motion. Optogenetic stimulation shows that TH2-ACs provide strong GABA

Indexed as

MotionAmacrine CellsAmino Acid Transport Systems, AcidicAnimalsBrainGene SilencingMiceNeural InhibitionOptogeneticsRetinaTime FactorsTyrosine 3-MonooxygenaseAmino Acid Transport Systems, AcidicSlc17a8 protein, mouseTyrosine 3-Monooxygenaseamacrine cellfeature selectivityobject motionretinasurround inhibitiontemporal coding

Identifiers

PMID28514655
PMCPMC5501491

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.